https://scholars.lib.ntu.edu.tw/handle/123456789/316501
標題: | Acute putaminal necrosis and white matter demyelination in a child with subnormal copper metabolism in Wilson disease: MR imaging and spectroscopic findings. | 作者: | Juan, C.J. Chen, C.Y. Liu, Y.J. Chin, S.C. Hsueh, C.J. Chu, H. Zimmerman, R.A. HSIAO-WEN CHUNG |
公開日期: | 2005 | 卷: | 47 | 期: | 6 | 起(迄)頁: | 401-405 | 來源出版物: | Neuroradiology. | 摘要: | Wilson disease (WD) that manifests solely with acute and severe neurological damage in the absence of hepatic disease and Kayser-Fleischer ring of the cornea is rare and difficult to diagnose at the acute setting. This report describes unusual diffusion and proton spectroscopic magnetic resonance (MR) imaging findings in a 12-year-old boy with WD who presented with hemichorea and subnormal copper metabolism. The MR imaging findings of lactate accumulation, decrease of N-acerylaspartate/creatinine (NAA/Cr) ratio and markedly increased apparent diffusion coefficient (ADC) value of the asymmetrical edematous putaminal lesions in the early stage were suggestive of acute necrosis with anaerobic metabolism of glucose leading to poor clinical outcome at follow-up. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33644804878&doi=10.1007%2fs00234-004-1306-z&partnerID=40&md5=69e1aeb520233b4e23ace8a3cf8837c1 http://scholars.lib.ntu.edu.tw/handle/123456789/316501 |
DOI: | 10.1007/s00234-004-1306-z | SDG/關鍵字: | copper; article; case report; child; demyelinating disease; human; male; metabolism; necrosis; nuclear magnetic resonance imaging; nuclear magnetic resonance spectroscopy; pathology; putamen; Wilson disease; Child; Copper; Demyelinating Diseases; Hepatolenticular Degeneration; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Necrosis; Putamen |
顯示於: | 生醫電子與資訊學研究所 |
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