https://scholars.lib.ntu.edu.tw/handle/123456789/332418
Title: | Molecular characterization of a new serotype of duck hepatitis virus | Authors: | Tseng, C.-H. HSIANG-JUNG TSAI |
Keywords: | DHV; Duck hepatitis virus; Genome analysis; Picornaviridae | Issue Date: | 2007 | Journal Volume: | 126 | Journal Issue: | 1-2 | Start page/Pages: | 19-31 | Source: | Virus Research | Abstract: | Duck hepatitis strains 90D and 04G were determined to be antigenically unrelated to type 1 duck hepatitis virus (DHV-1) by in vitro cross-neutralization assay. The genome sequences of 90D and 04G revealed that both strains of the new serotype DHV (N-DHV) possessed a typical picornavirus genome organization apart from the unique possession of three in-tandem 2A genes present in DHV-1. The 2A1, 2A2, and 2A3 proteins represented an aphthovirus-like 2A protein, AIG1-like protein, and human parechovirus-like 2A protein, respectively. The N-DHV genome displayed unique features, compared to the DHV-1 genome. The 366 nt 3′UTR of N-DHV, the largest determined thus far among picornaviruses, was 52 nt longer than DHV-1. The pairwise percent identity of the nucleic acid and amino acid sequences at 1D region of N-DHV and DHV-1 were only 69.1-69.7 and 70.1-70.5%, respectively. Finally, phylogenetic and evolutionary analysis of N-DHV revealed that the N-DHV and DHV-1 belong to two different clusters of a novel genus in the Picornaviridae family. ? 2007 Elsevier B.V. All rights reserved. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-34248158854&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/332418 |
DOI: | 10.1016/j.virusres.2007.01.012 | SDG/Keyword: | Aphthovirus like 2a protein; unclassified drug; virus protein; 3' untranslated region; article; comparative study; gene sequence; genome analysis; hepatitis virus; molecular biology; molecular evolution; nonhuman; nucleotide sequence; phylogeny; Picornavirus; priority journal; serodiagnosis; serotype; virus gene; virus strain; 5' Untranslated Regions; Amino Acid Sequence; Animals; Antigens, Viral; Base Sequence; Cross Reactions; DNA, Viral; Ducks; Evolution, Molecular; Genome, Viral; Hepatitis Virus, Duck; Hepatitis, Viral, Animal; Humans; Molecular Sequence Data; Neutralization Tests; Nucleic Acid Conformation; Phylogeny; Picornaviridae Infections; RNA, Viral; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Serotyping; Viral Proteins; Aphthovirus; Duck hepatitis B virus; Human parechovirus; Picornaviridae |
Appears in Collections: | 獸醫學系 |
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