https://scholars.lib.ntu.edu.tw/handle/123456789/335603
Title: | Iron overload and unique susceptibility of liver transplant recipients to disseminated disease due to opportunistic pathogens | Authors: | HSIN-YUN SUN | Issue Date: | 2008 | Journal Volume: | 14 | Journal Issue: | 9 | Start page/Pages: | 1249-1255 | Source: | Liver Transplantation | Abstract: | The propensity of liver transplant recipients to develop more fulminant disease presentation and a higher risk of disseminated disease due to a number of opportunistic infections, including invasive aspergillosis, cryptococcosis, zygomycosis, may be related to iron overload. Abnormalities in iron homeostasis may also be a contributor to severe manifestations due to other pathogens such as cytornegalovirus and Staphylococcus aureus in liver transplant recipients. Iron is essential not only for microbial pathogenesis, but directly impairs pivotal pathogen specific host defenses. Studies to assess iron homeostasis and the mechanisms by which iron overload contributes to the pathogenesis of opportunistic infections in liver transplant recipients are warranted. ? 2008 AASLD. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-51349152242&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/335603 |
DOI: | 10.1002/lt.21587 | SDG/Keyword: | alpha interferon; CD4 antigen; CD8 antigen; deferoxamine; ferroportin; gamma interferon; hepcidin; iron binding protein; rapamycin; adaptive immunity; aspergillosis; CD4+ T lymphocyte; CD8+ T lymphocyte; cryptococcosis; cytomegalovirus infection; cytotoxic T lymphocyte; disease association; disease predisposition; disease severity; graft recipient; high risk patient; host resistance; human; innate immunity; iron overload; liver transplantation; molecular mechanics; mucormycosis; nonhuman; opportunistic infection; priority journal; review; Staphylococcus aureus; Aspergillosis; Cryptococcosis; Cryptococcus; Cytomegalovirus; Hepacivirus; Homeostasis; Humans; Iron; Iron Overload; Liver Transplantation; Opportunistic Infections; Simplexvirus; Staphylococcus aureus; T-Lymphocytes, Helper-Inducer; Zygomycosis |
Appears in Collections: | 醫學系 |
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