https://scholars.lib.ntu.edu.tw/handle/123456789/345283
標題: | Urinary epidermal growth factor excretion in children with chronic renal failure | 作者: | YONG-KWEI TSAU | 關鍵字: | Chronic renal failure; Creatinine clearance; Epidermal growth factor; Lupus nephritis | 公開日期: | 1999 | 卷: | 19 | 期: | 3 | 起(迄)頁: | 400-404 | 來源出版物: | American Journal of Nephrology | 摘要: | To investigate the excretion of urinary epidermal growth factor (EGF) in children with chronic renal failure (CRF), we have measured the urinary EGF/creatinine ratio (EGF/Cr) and the 24-hour urine EGF concentration in 19 children with CRF, 11 children with kidney disease and normal creatinine clearance, and 12 healthy children. Children with CRF had a significantly lower daily urine EGF concentration as well as urinary EGF/Cr. In contrast, children with kidney disease and normal renal function had normal daily urine EGF levels and urinary EGF/Cr. Accompanied by no difference in serum EGF between these two groups of patients, these data provide indirect evidence of the kidney as a source of human urinary EGF. There was a positive correlation of urinary EGF/Cr with creatinine clearance in all renal patients (r = 0.608, n = 30, p < 0.001). A much better correlation was found between daily urine EGF and creatinine clearance (r = 0.855, n = 30, p < 0.001). Our results implicate that there is a functional relationship between glomerular filtration and urinary EGF excretion, and that the urinary EGF/Cr may be a reliable indicator of urinary EGF excretion in children with CRF. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-0033002259&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/345283 |
DOI: | 10.1159/000013485 | SDG/關鍵字: | creatinine; epidermal growth factor; adolescent; article; blood level; child; chronic kidney failure; clinical article; controlled study; correlation function; creatinine clearance; glomerulus filtration; human; lupus erythematosus nephritis; priority journal; urinary excretion; Case-Control Studies; Child; Creatinine; Epidermal Growth Factor; Humans; Kidney Failure, Chronic |
顯示於: | 醫學系 |
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