https://scholars.lib.ntu.edu.tw/handle/123456789/347305
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | HAI-GWO HWU | en |
dc.contributor.author | Glatt, S J | en |
dc.contributor.author | Faraone, S V | en |
dc.contributor.author | Lasky-Su, J A | en |
dc.contributor.author | Kanazawa, T | en |
dc.contributor.author | Hwu, H-G | en |
dc.contributor.author | Tsuang, M T | en |
dc.creator | Glatt, S.J.;Faraone, S.V.;Lasky-Su, J.A.;Kanazawa, T.;Hwu, H.-G.;Tsuang, M.T.Glatt, Sj; Faraone, Sv; Lasky-Su, Ja; Kanazawa, T; Hwu, H-G; Tsuang, Mt;Glatt, S J; Faraone, S V; Lasky-Su, J A; Kanazawa, T; Hwu, H-G; Tsuang, M T | - |
dc.date.accessioned | 2018-09-10T07:28:02Z | - |
dc.date.available | 2018-09-10T07:28:02Z | - |
dc.date.issued | 2009 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-69249123764&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/347305 | - |
dc.description.abstract | The gene that codes for dopamine receptor D2 (DRD2 on chromosome 11q23) has long been a prime functional and positional candidate risk gene for schizophrenia. Collectively, prior case-control studies found a reliable effect of the Ser311Cys DRD2 polymorphism (rs1801028) on risk for schizophrenia, but few other polymorphisms in the gene had ever been evaluated and no adequately powered family-based association study has been performed to date. Our objective was to test 21 haplotype-tagging and all three known nonsynonymous single-nucleotide polymorphisms (SNPs) in DRD2 for association with schizophrenia in a family-based study of 2408 Han Chinese, including 1214 affected individuals from 616 families. We did not find a significant effect of rs1801028, but we did find significant evidence for association of schizophrenia with two multi-marker haplotypes spanning blocks of strong linkage disequilibrium (LD) and nine individual SNPs (Ps0.05). Importantly, two SNPs (rs1079727 and rs2283265) and both multi-marker haplotypes spanning entire LD blocks (including one that contained rs1801028) remained significant after correcting for multiple testing. These results further add to the body of data implicating DRD2 as a schizophrenia risk gene; however, a causal variant(s) in DRD2 remains to be elucidated by further fine mapping of the gene, with particular attention given to the area surrounding the third through fifth exons. ? 2009 Nature Publishing Group. | - |
dc.language | en | en |
dc.relation | Molecular Psychiatry. | en |
dc.relation.ispartof | Molecular Psychiatry | en_US |
dc.source | AH | - |
dc.subject | Allele; Dopamine; Haplotype; Linkage disequilibrium; PBAT | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | dopamine 2 receptor; article; Chinese; controlled study; female; gene linkage disequilibrium; gene mapping; genetic risk; genetic variability; haplotype; human; male; priority journal; schizophrenia; single nucleotide polymorphism; Asian Continental Ancestry Group; Case-Control Studies; Cysteine; Family Health; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Linkage Disequilibrium; Male; Polymorphism, Single Nucleotide; Receptors, Dopamine D2; Risk; Schizophrenia; Serine; Taiwan | - |
dc.title | Family-based association testing strongly implicates DRD2 as a risk gene for schizophrenia in Han Chinese from Taiwan | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/mp.2008.30 | - |
dc.relation.pages | 885-893 | - |
dc.relation.journalvolume | 14 | - |
dc.relation.journalissue | 9 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Psychology | - |
crisitem.author.dept | Neurobiology and Cognitive Science Center | - |
crisitem.author.orcid | 0000-0002-2582-2807 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Science | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。