https://scholars.lib.ntu.edu.tw/handle/123456789/350380
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | HSIAO-WEN CHUNG | en_US |
dc.date.accessioned | 2018-09-10T07:36:59Z | - |
dc.date.available | 2018-09-10T07:36:59Z | - |
dc.date.issued | 2009 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-59249108362&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/350380 | - |
dc.description.abstract | We aimed to quantitatively investigate the alteration of parotid perfusion after irradiation using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) based on a two-compartment tracer kinetic model. This study enrolled 19 patients (53.2 ± 14.9 years) treated by head and neck radiotherapy and 19 age-relevant and sex-matched subjects as a control group. Perfusion parameters (Kel, k21 and A) of parotid glands were analyzed based on the Brix model from T1-weighted DCE-MRI. Suitability of the Brix model was evaluated via Monte Carlo simulation for the goodness-of-fit. Analysis of nonlinear goodness-of-fit showed that the Brix model is appropriate in evaluating the parotid perfusion (R2 = 0.938 ± 0.050). The irradiated parotid glands showed significantly lower Kel(P < 0.0005) and k21 (P < 0.05) and consequently significantly higher value of peak enhancement (P < 0.0005) and time-to-peak (P < 0.0005) compared with non-irradiated ones, suggestive of gradual and prolonged accumulation and delayed wash-out of contrast agent due to increased extracellular extravascular space and decreased vascular permeability in the irradiated glands. Linear regression analysis showed dose-dependent perfusion changes of the irradiated parotid glands. We conclude that quantitative DCE-MRI is a potential tool in investigating parotid gland perfusion changes after radiotherapy. ? European Society of Radiology 2008. | - |
dc.language | en | en |
dc.relation.ispartof | European Radiology | en_US |
dc.source | AH-Scopus to ORCID | - |
dc.subject | Magnetic resonance imaging; Parotid glands; Perfusion; Radiation injury | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | gadolinium pentetate; adult; article; blood vessel permeability; cancer radiotherapy; clinical article; contrast enhancement; controlled study; drug elimination; female; flow kinetics; human; male; nuclear magnetic resonance imaging; parotid gland disease; priority journal; quantitative analysis; radiation dose; radiation injury; tissue perfusion; xerostomia; Adult; Aged; Contrast Media; Female; Gadolinium DTPA; Head and Neck Neoplasms; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Parotid Gland; Radiation Injuries; Reproducibility of Results; Sensitivity and Specificity; Xerostomia; Young Adult | - |
dc.title | Perfusion characteristics of late radiation injury of parotid glands: Quantitative evaluation with dynamic contrast-enhanced MRI | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1007/s00330-008-1104-9 | - |
dc.relation.pages | 94-102 | - |
dc.relation.journalvolume | 19 | - |
dc.relation.journalissue | 1 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Electrical Engineering | - |
crisitem.author.orcid | 0000-0001-7127-1244 | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
顯示於: | 生醫電子與資訊學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。