https://scholars.lib.ntu.edu.tw/handle/123456789/350383
Title: | Correlation between the MR T2 value at 4.7 T and relative water content in articular cartilage in experimental osteoarthritis induced by ACL transection | Authors: | Chou, M.-C. Tsai, P.-H. Huang, G.-S. Lee, H.-S. Lee, C.-H. Lin, M.-H. Lin, C.-Y. HSIAO-WEN CHUNG |
Keywords: | ACL transection; Cartilage degeneration; Cartilage T2; Water content | Issue Date: | 2009 | Journal Volume: | 17 | Journal Issue: | 4 | Start page/Pages: | 441-447 | Source: | Osteoarthritis and Cartilage | Abstract: | Objective: Both animal and human studies using magnetic resonance imaging (MRI) show that cartilage degeneration increases the T2 value. However, it is unclear whether the T2 value correlates linearly with water content in cartilage with osteoarthritis. The purpose of this study was to investigate the relationship between the T2 value and water content using an animal model of cartilage injury measured at 4.7 T. Design: Thirty Sprague Dawley rats were randomly separated into three groups (n = 10 for each group). Group 1 rats were not operated on (control). Group 2 rats received a sham operation, and group 3 rats received an anterior cruciate ligament (ACL) transection. Six rats of each group were randomly assigned to T2 measurement and later subjected to ex vivo analysis of the relative water content of the knee cartilage. The other four rats in each group were killed, and the severity of cartilage degeneration was examined histologically. The knees of the six rats in the ACL transection group were imaged sequentially 4 and 13 weeks after ACL transection, and the relative water content was measured at 13 weeks. Results: The cartilage T2 value was significantly higher 4 and 13 weeks after ACL transection in the operated knees than in the knees of the control and sham groups. The cartilage T2 value was significantly higher at 13 weeks than at 4 weeks in the operated knees. The T2 value was strongly positively correlated with the relative water content (R = 0.885, P < 0.0001). Conclusion: The trend of changes in the T2 values is consistent with an increase in the relative water content in our cartilage degeneration model. This model has potential use for the clinical evaluation of osteoarthritis. ? 2008 Osteoarthritis Research Society International. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-61549121095&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/350383 |
DOI: | 10.1016/j.joca.2008.09.009 | SDG/Keyword: | animal experiment; animal model; animal tissue; anterior cruciate ligament; article; articular cartilage; cartilage degeneration; controlled study; ex vivo study; histology; image processing; knee osteoarthritis; male; measurement; nonhuman; nuclear magnetic resonance imaging; priority journal; rat; water content; animal; Arthritis, Experimental; body water; Cartilage Diseases; complication; edema; nuclear magnetic resonance imaging; osteoarthritis; pathology; procedures; Sprague Dawley rat; Animals; Anterior Cruciate Ligament; Arthritis, Experimental; Body Water; Cartilage Diseases; Cartilage, Articular; Edema; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Osteoarthritis; Rats; Rats, Sprague-Dawley; Animals; Anterior Cruciate Ligament; Arthritis, Experimental; Body Water; Cartilage Diseases; Cartilage, Articular; Edema; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Osteoarthritis; Rats; Rats, Sprague-Dawley [SDGs]SDG3 |
Appears in Collections: | 生醫電子與資訊學研究所 |
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