https://scholars.lib.ntu.edu.tw/handle/123456789/351251
Title: | Hepatitis B vaccination: The key towards elimination and eradication of hepatitis B | Authors: | DING-SHINN CHEN | Keywords: | Elimination of hepatitis B; Eradication of hepatitis B; Hepatitis B vaccine; Hepatitis B virus; Universal hepatitis B vaccination | Issue Date: | 2009 | Journal Volume: | 50 | Journal Issue: | 4 | Start page/Pages: | 805-816 | Source: | Journal of Hepatology | Abstract: | Hepatitis B virus infection is a global health problem. Worldwide, about 360 million people are chronically infected with the virus. They continue to spread the virus to others and are themselves at risk of chronic liver diseases and hepatocellular carcinoma. The infection can now be treated by antivirals or interferons and the transmission route can be interrupted. Nevertheless, the most effective means is to immunize all susceptible individuals, especially young children, with safe and efficacious vaccines. The combined efforts of vaccination, effective treatment and interruption of transmission make elimination of the infection plausible and may eventually lead to eradication of the virus. Because hepatitis B vaccination has a key role in the control of hepatitis B, properties of this vaccine, its effectiveness in pre-exposure and post-exposure settings, duration of protection after vaccination and the need of booster doses are discussed. Mass hepatitis B vaccination in children decreases the carriage of the virus, and the diseases associated with acute and chronic infection, including hepatocellular carcinoma. Challenges that need to be solved to expand mass vaccination, and the strategies towards elimination and eventual eradication of hepatitis B in the world are also discussed. ? 2009 European Association for the Study of the Liver. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-61849176483&doi=10.1016%2fj.jhep.2009.01.002&partnerID=40&md5=10c28010ecf92865fc663d05494bfd9d http://scholars.lib.ntu.edu.tw/handle/123456789/351251 |
DOI: | 10.1016/j.jhep.2009.01.002 | SDG/Keyword: | DNA vaccine; hepatitis B surface antigen; hepatitis B vaccine; anaphylaxis; chronic fatigue syndrome; drug cost; drug dose increase; drug efficacy; drug safety; fever; Guillain Barre syndrome; hair loss; health care delivery; health education; hearing loss; hepatitis B; human; idiopathic thrombocytopenic purpura; injection site pain; insulin dependent diabetes mellitus; leukemia; lichen planus; lichenoid; liver cell carcinoma; macrophagic myofasciitis; mass immunization; multiple sclerosis; muscle disease; myelitis; optic neuritis; priority journal; public health service; retina vein occlusion; review; rheumatoid arthritis; skin lupus erythematosus; sudden infant death syndrome; vaccination; vasculitis; Female; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Humans; Infant; Infant, Newborn; Mothers; Taiwan; Vaccination |
Appears in Collections: | 醫學系 |
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