https://scholars.lib.ntu.edu.tw/handle/123456789/356091
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | HAI-GWO HWU | en |
dc.creator | Chan, H.Y.;Chang, C.J.;Chiang, S.C.;Chen, J.J.;Chen, C.H.;Sun, H.J.;Hwu, H.G.;Lai, M.S. | - |
dc.date.accessioned | 2018-09-10T08:08:55Z | - |
dc.date.available | 2018-09-10T08:08:55Z | - |
dc.date.issued | 2010 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-76249100309&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/356091 | - |
dc.description.abstract | The objective of this study was to compare the effects of risperidone and olanzapine in schizophrenic patients with intolerant extrapyramidal side effects (EPS) on first generation antipsychotics. We conducted an 8-week, rater-blinded, flexible dose study. Seventy patients with schizophrenia, who met the DSM-IV research criteria of having neuroleptic-induced acute dystonia or parkinsonism, were randomly assigned to risperidone or olanzapine group. The primary outcome was a comparison of the incidence of concomitant anticholinergic drugs usage between the groups to manage their acute dystonia and parkinsonism. The average doses of risperidone and olanzapine from baseline to study end point were 1.8-3.5 mg/day and 7.7-11.7 mg/day, respectively. There were no significant differences in demographic data, severity of EPS or psychotic symptoms between the groups at baseline assessment. Patients taking risperidone had significantly higher incidence of using anticholinergic drugs to manage acute dystonia or parkinsonism overall during the study (OR = 5.17, 95%CI = 1.49-17.88, P = 0.013). There was no significant between-group difference in the changing of rating scales of EPS and psychotic symptoms. The results of our study favour olanzapine as a better choice in schizophrenic patients with intolerant EPS. Double-blinded, fixed dose and different ethnical study for EPS-intolerant schizophrenic patients is needed to confirm the results of our study. ? 2010 British Association for Psychopharmacology. | - |
dc.language | en | en |
dc.relation.ispartof | Journal of Psychopharmacology | en_US |
dc.source | AH | - |
dc.subject | EPS-intolerant; Olanzapine; Risperidone; Schizophrenia | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | benzodiazepine; chlorpromazine; clopenthixol; clotiapine; flupentixol; haloperidol; loxapine; olanzapine; pipotiazine; propranolol; risperidone; sulpiride; thioridazine; trifluoperazine; zotepine; adult; aged; akathisia; article; blurred vision; clinical trial; comparative study; constipation; controlled clinical trial; controlled study; demography; diagnostic and statistical manual of mental disorders; disease severity; drowsiness; dystonia; extrapyramidal symptom; female; headache; heart palpitation; human; major clinical study; male; nausea; orthostatic hypotension; parkinsonism; priority journal; psychosis; randomized controlled trial; schizophrenia; side effect; thirst; weakness; weight gain; Adult; Antipsychotic Agents; Benzodiazepines; Dose-Response Relationship, Drug; Dystonia; Female; Humans; Male; Middle Aged; Parkinsonian Disorders; Risperidone; Schizophrenia; Severity of Illness Index; Single-Blind Method | - |
dc.title | A randomised controlled study of risperidone and olanzapine for schizophrenic patients with neuroleptic-induced acute dystonia or parkinsonism | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1177/0269881108096070 | - |
dc.relation.pages | 91-98 | - |
dc.relation.journalvolume | 24 | - |
dc.relation.journalissue | 1 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Psychology | - |
crisitem.author.dept | Neurobiology and Cognitive Science Center | - |
crisitem.author.orcid | 0000-0002-2582-2807 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Science | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
顯示於: | 醫學系 |
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