|Title:||Biocompatibility of Fe3O4 nanoparticles evaluated by in vitro cytotoxicity assays using normal, glia and breast cancer cells||Authors:||Ankamwar, B.
Lai, T. C.
Huang, J. H.
Liu, R. S.
Chen, C. H.
Hwu, Y. K.
|Issue Date:||2010||Journal Volume:||21||Journal Issue:||7||Source:||Nanotechnology||Abstract:||
In order to reveal the biocompatibility of Fe3O4 nanoparticles and bipolar surfactant tetramethylammonium 11-aminoundecanoate cytotoxicity tests were performed as a function of concentration from low (0.1νgml-1) to higher concentration (100νgml-1) using various human glia, human breast cancer and normal cell lines. Cytotoxicity tests for human glia (D54MG, G9T, SF126, U87, U251, U373), human breast cancer (MB157, SKBR3, T47D) and normal (H184B5F5/M10, WI-38, SVGp12) cell lines exhibited almost nontoxicity and reveal biocompatibility of Fe 3O4 nanoparticles in the concentration range of 0.1-10νgml-1, while accountable cytotoxicity can be seen at 100νgml-1. The results of our studies suggest that Fe 3O4 nanoparticles coated with bipolar surfactant tetramethylammonium 11-aminoundecanoate are biocompatible and promising for bio-applications such as drug delivery, magnetic resonance imaging and magnetic hyperthermia. ? 2010 IOP Publishing Ltd.
|DOI:||10.1088/0957-4484/21/7/075102||metadata.dc.subject.other:||Breast cancer cells; Cell lines; Concentration ranges; Cytotoxicity test; Human breast cancer; In-vitro; Magnetic hyperthermia; Non-toxicity; Tetramethylammonium; Biocompatibility; Cell culture; Cells; Cytotoxicity; Diseases; Drug delivery; Magnetic resonance imaging; Nanoparticles; Surface active agents; Nanomagnetics; 11 aminoundecanoic acid; 11-aminoundecanoic acid; amino acid; biomaterial; ferric ion; ferric oxide; metal nanoparticle; quaternary ammonium derivative; surfactant; tetramethylammonium; article; breast; breast tumor; cell line; cell survival; chemistry; cytology; drug effect; female; glia; human; materials testing; metabolism; methodology; microscopy; pathology; tumor cell line; Amino Acids; Biocompatible Materials; Breast; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Survival; Female; Ferric Compounds; Humans; Materials Testing; Metal Nanoparticles; Microscopy; Neuroglia; Quaternary Ammonium Compounds; Surface-Active Agents
|Appears in Collections:||化學系|
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