https://scholars.lib.ntu.edu.tw/handle/123456789/358343
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Yao, C.-H. | en_US |
dc.contributor.author | Lin, K.-J. | en_US |
dc.contributor.author | Weng, C.-C. | en_US |
dc.contributor.author | Hsiao, I.-T. | en_US |
dc.contributor.author | Ting, Y.-S. | en_US |
dc.contributor.author | Yen, T.-C. | en_US |
dc.contributor.author | TONG-RONG JAN | en_US |
dc.contributor.author | Skovronsky, D. | en_US |
dc.contributor.author | Kung, M.-P. | en_US |
dc.contributor.author | Wey, S.-P. | en_US |
dc.creator | Yao, C.-H.;Lin, K.-J.;Weng, C.-C.;Hsiao, I.-T.;Ting, Y.-S.;Yen, T.-C.;Jan, T.-R.;Skovronsky, D.;Kung, M.-P.;Wey, S.-P. | - |
dc.date.accessioned | 2018-09-10T08:15:29Z | - |
dc.date.available | 2018-09-10T08:15:29Z | - |
dc.date.issued | 2010 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-77956412778&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/358343 | - |
dc.description.abstract | We report herein the Good Manufacturing Practice (GMP)-compliant automated synthesis of 18F-labeled styrylpyridine, AV-45 (Florbetapir), a novel tracer for positron emission tomography (PET) imaging of Β-amyloid (AΒ) plaques in the brain of Alzheimer's disease patients. [18F]AV-45 was prepared in 105min using a tosylate precursor with Sumitomo modules for radiosynthesis under GMP-compliant conditions. The overall yield was 25.4±7.7% with a final radiochemical purity of 95.3±2.2% (n=19). The specific activity of [18F]AV-45 reached as high as 470±135TBq/mmol (n=19). The present studies show that [18F]AV-45 can be manufactured under GMP-compliant conditions and could be widely available for routine clinical use. ? 2010 Elsevier Ltd. | - |
dc.language | en | en |
dc.relation.ispartof | Applied Radiation and Isotopes | en_US |
dc.source | AH-Scopus to ORCID | - |
dc.subject | Β-amyloid plaque imaging; Alzheimer's disease; PET tracer synthesis | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Alzheimer's disease; Amyloid plaques; Automated synthesis; Clinical use; Good Manufacturing Practices; Human brain; PET tracer; Radiochemical purity; Radiosynthesis; Specific activity; Sumitomo; Diseases; Glycoproteins; Proteins; Positron emission tomography; 2 [2 [2 [5 [4 [tert butoxycarbonyl(methyl)amino]styryl]pyridin 2 yloxy]ethoxy]ethoxy]ethyl 4 methylbenzenesulfonate f 18; amyloid beta protein; radiopharmaceutical agent; unclassified drug; Alzheimer disease; article; automation; drug purification; drug specificity; drug synthesis; good manufacturing practice; isotope analysis; molecular imaging; neuroimaging; positron emission tomography; priority journal; radioactivity; radiochemistry; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Automation; Chromatography, High Pressure Liquid; Ethylene Glycols; Fluorine Radioisotopes; Guideline Adherence; Humans; Positron-Emission Tomography | - |
dc.title | GMP-compliant automated synthesis of [<sup>18</sup>F]AV-45 (Florbetapir F 18) for imaging Β-amyloid plaques in human brain | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.apradiso.2010.07.001 | - |
dc.relation.pages | 2293-2297 | - |
dc.relation.journalvolume | 68 | - |
dc.relation.journalissue | 12 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
crisitem.author.dept | Veterinary Medicine | - |
crisitem.author.orcid | 0000-0003-2771-8381 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
顯示於: | 獸醫學系 |
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