|dc.creator||Chen, C.-H. and Chen, R.-J.||-|
|dc.description.abstract||Telomerase activity has been measured in a wide variety of cancerous and non-cancerous tissue types, and the vast majority of clinical studies have shown a direct correlation between it and the presence of cancerous cells. Telomerase plays a key role in cellular immortality and tumorigenesis. Telomerase is activated in 80-90% of human carcinomas, but not in normal somatic cells, therefore, its detection holds promise as a diagnostic marker for cancer. Measurable levels of telomerase have been detected in malignant cells from various samples: tissue from gestational trophoblastic neoplasms; squamous carcinoma cells from oral rinses; lung carcinoma cells from bronchial washings; colorectal carcinoma cells from colonic luminal washings; bladder carcinoma cells from urine or bladder washings; and breast carcinoma or thyroid cancer cells from fine needle aspirations. Such clinical tests for telomerase can be useful as non-invasive and costeffective methods for early detection and monitoring of cancer. In addition, telomerase activity has been shown to correlate with poor clinical outcome in late-stage diseases such as non-small cell lung cancer, colorectal cancer, and soft tissue sarcomas. In such cases, testing for telomerase activity can be used to identify patients with a poor prognosis and to select those who might benefit from adjuvant treatment. Our review of the latest medical advances in this field reveals that telomerase holds great promise as a biomarker for early cancer detection and monitoring, and has considerable potential as the basis for developing new anticancer therapies. ? 2011 Elsevier & Formosan Medical Association.||-|
|dc.relation.ispartof||Journal of the Formosan Medical Association||-|
|dc.subject.other||telomerase; tumor marker; bladder carcinoma; cancer adjuvant therapy; cancer diagnosis; carcinogenesis; colorectal cancer; colorectal carcinoma; early diagnosis; enzyme activation; enzyme activity; human; lung carcinoma; lung non small cell cancer; prognosis; review; soft tissue sarcoma; squamous cell carcinoma; trophoblastic tumor||-|
|dc.title||Prevalence of telomerase activity in human cancer||-|
|Appears in Collections:||醫學系|
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