https://scholars.lib.ntu.edu.tw/handle/123456789/363062
標題: | Well-defined mesoporous nanostructure modulates three-dimensional interface energy transfer for two-photon activated photodynamic therapy | 作者: | Cheng, Shih-Hsun Hsieh, Cheng-Chih Chen, Nai-Tzu Chu, Chia-Hui Huang, Ching-Mao PI-TAI CHOU Tseng, Fan-Gang Yang, Chung-Shi CHUNG-YUAN MOU Lo, Leu-Wei |
關鍵字: | Energy transfer; Mesoporous silica nanoparticles; Two-photon activated-photodynamic therapy | 公開日期: | 2011 | 卷: | 6 | 期: | 6 | 起(迄)頁: | 552-563 | 來源出版物: | Nano Today | 摘要: | Two-photon activated-photodynamic therapy (TPA-PDT) allows for spatially selective treatment of cancers, and enhances the tissue penetration depth of incident light. The three dimensional (3D) interface energy transfers in hexagonal mesoporous silica nanoparticles (MSNs) can significantly enhance the photodynamic effect. By providing a well-defined mesoporous nanostructure, we established an efficient and controllable energy transfer mechanism via the facile modification of a two-photon antenna molecule and photosensitizer on different topological domains in the MSN. The cytotoxicity induced by the singlet oxygen, generated following relay of energy transfer, was demonstrated in both in vitro and in vivo breast cancer models. Therefore, our results contribute new insight to the highly efficient energy transfer within a single nanoparticle for two-photon activated PDT, worthwhile for studying its potential for development in clinical translation. ? 2011 Elsevier Ltd. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-82955233185&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/363062 |
DOI: | 10.1016/j.nantod.2011.10.003 | SDG/關鍵字: | Breast cancer models; Clinical translation; Efficient energy transfer; Facile modifications; Hexagonal mesoporous silica; In-vitro; Incident light; Mesoporous; Mesoporous silica nanoparticles; Photodynamic effect; Selective treatment; Single nanoparticle; Singlet oxygen; Three dimensional (3D) interfaces; Three dimensional interface; Transfer mechanisms; Two photon; Diseases; Energy efficiency; Energy transfer; Mesoporous materials; Nanoparticles; Photons; Photosensitizers; Silica; Three dimensional; Tissue; Photodynamic therapy; fluorescein isothiocyanate; nanomaterial; photosensitizing agent; silicon dioxide; singlet oxygen; article; breast cancer; chemical modification; cytotoxicity; energy transfer; in vitro study; in vivo study; molecule; photodynamic therapy; three dimensional imaging; two photon activated photodynamic therapy |
顯示於: | 化學系 |
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