https://scholars.lib.ntu.edu.tw/handle/123456789/363593
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chao, C.-H. | en_US |
dc.contributor.author | Chou, K.-J. | en_US |
dc.contributor.author | Huang, C.-Y. | en_US |
dc.contributor.author | Wen, Z.-H. | en_US |
dc.contributor.author | Hsu, C.-H. | en_US |
dc.contributor.author | Wu, Y.-C. | en_US |
dc.contributor.author | CHANG-FENG DAI | en_US |
dc.contributor.author | Sheu, J.-H. | en_US |
dc.creator | Chao, C.-H.;Chou, K.-J.;Huang, C.-Y.;Wen, Z.-H.;Hsu, C.-H.;Wu, Y.-C.;Dai, C.-F.;Sheu, J.-H. | - |
dc.date.accessioned | 2018-09-10T08:37:57Z | - |
dc.date.available | 2018-09-10T08:37:57Z | - |
dc.date.issued | 2011 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-80054891417&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/363593 | - |
dc.description.abstract | Eight new cembranoids, crassarines A-H (1-8) were isolated from the Formosan soft coral Sinularia crassa. Compounds 1-3 represent the rare cembranoids with a 1,12-oxa-bridged tetrahydrofuran ring, while 4 and 5 are the firstly discovered 1,11-oxa-bridged tetrahydropyranocembranoids. The absolute configuration of 6 was determined using the Mosher's method. Compounds 6 and 8 were found to significantly inhibit the expression of both pro-inflammatory iNOS and COX-2 proteins at 10 μM, respectively, while compounds 4-8 were found to be non-cytotoxic toward the selected human liver cancer cells. ? 2011 by the authors; licensee MDPI. | - |
dc.language | en | en |
dc.relation.ispartof | Marine Drugs | - |
dc.source | AH | - |
dc.subject | Anti-inflammatory; Crassarines A-H; Sinularia crassa | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | cembranoid; crassarine A; crassarine B; crassarine C; crassarine D; crassarine E; crassarine F; crassarine G; crassarine H; cyclooxygenase 2; inducible nitric oxide synthase; unclassified drug; animal cell; antiinflammatory activity; article; cancer cell; concentration response; controlled study; coral; drug cytotoxicity; drug isolation; drug structure; human; human cell; liver cancer; nonhuman; protein expression; Sinularia crassa; Taiwan; Alcyonacea; Sinularia | - |
dc.title | Bioactive cembranoids from the soft coral Sinularia crassa | - |
dc.type | journal article | en |
dc.identifier.doi | 10.3390/md9101955 | - |
dc.identifier.scopus | 2-s2.0-80054891417 | - |
dc.identifier.isi | WOS:000298928300013 | - |
dc.relation.pages | 1955-1968 | - |
dc.relation.journalvolume | 9 | - |
dc.relation.journalissue | 10 | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
crisitem.author.orcid | 0000-0003-2242-5643 | - |
顯示於: | 海洋研究所 |
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