DC Field | Value | Language |
dc.contributor | 臺大醫院雲林分院;臺大醫院-精神醫學部; | - |
dc.contributor.author | CHIH-MIN LIU | en |
dc.contributor.author | Chang, Li-Ren | en |
dc.contributor.author | LI-REN CHANG | en |
dc.contributor.author | Lin, Yu-Hsuan | en |
dc.contributor.author | Kuo, Terry B. J. | en |
dc.contributor.author | Ho, Yen-Cheng | en |
dc.contributor.author | Chen, Shiuan-Horng | en |
dc.contributor.author | Chang, Hung-Chieh Wu | en |
dc.contributor.author | Liu, Chih-Min | en |
dc.contributor.author | Yang, Cheryl C. H. | en |
dc.creator | Chang, Li-Ren;Lin, Yu-Hsuan;Kuo, Terry B. J.;Ho, Yen-Cheng;Chen, Shiuan-Horng;Chang, Hung-Chieh Wu;Liu, Chih-Min;Yang, Cheryl C. H. | - |
dc.creator | 林煜軒;劉智民;張立人;吳張弘杰 | zh-tw |
dc.date.accessioned | 2018-09-10T09:12:55Z | - |
dc.date.available | 2018-09-10T09:12:55Z | - |
dc.date.issued | 2012 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84862777110&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/367808 | - |
dc.description.abstract | Background: Methadone therapy benefits heroin users in both the medical and psychosocial dimensions. However, both heroin and methadone have cardiac toxicity. Only limited information is available describing the changes in cardiac autonomic function of heroin users and effects of methadone therapy. We conduct the current study to explore the cardiac vagal function in heroin users as well as the impact of lapse and methadone therapy. Methods: 80 heroin users from a methadone therapy clinic were distributed into 31 compliant and 49 incompliant patients according to whether they lapsed into heroin use within 10. days. 40 healthy control subjects were recruited from the community. Participants underwent electrocardiographic recordings and the heroin users were further investigated before and after methadone therapy. Spectral analysis of heart rate variability (HRV) was computed for cardiac parasympathetic modulation (high-frequency power, HF) and cardiac sympathetic modulation (normalized low-frequency power, LF%). Results: The baseline HRV parameters found lower HF values for heroin users and lower RR interval values for patients with a recent lapse compared with the healthy control subjects. After 1. h of methadone administration, heroin users who had lapsed showed a significant increase in HF but the heroin users who had not lapsed did not. Conclusion: Our findings suggest that heroin users show decreased cardiac vagal activity and that methadone therapy immediately facilitates vagal regulation in patients with a recent lapse. The differential patterns of autonomic alteration under methadone between those with and without lapse might offer an objective measure of lapse. ? 2012 Elsevier Inc. | - |
dc.format.extent | 109 bytes | - |
dc.format.mimetype | text/html | - |
dc.language | en | en |
dc.relation | Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 37(1), 188-193 | - |
dc.relation.ispartof | Progress in Neuro-Psychopharmacology and Biological Psychiatry | en_US |
dc.source | AH | - |
dc.subject | Autonomic nervous system; Heart rate variability; Heroin; Methadone; Opioid | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | alcohol; barbituric acid derivative; cannabis; diamorphine; methadone; opiate; psychedelic agent; tranquilizer; adult; article; Asian; autonomic dysfunction; cardiac vagal depression; cardiovascular function; controlled study; diastolic blood pressure; electrocardiogram; female; heart function; heart rate variability; heroin dependence; human; major clinical study; male; methadone treatment; morning dosage; parasympathetic tone; patient compliance; pilot study; power spectrum; recurrence risk; RR interval; sympathetic tone; systolic blood pressure; Adult; Autonomic Nervous System; Blood Pressure; Electrocardiography; Female; Heart Rate; Heroin Dependence; Humans; Male; Medication Adherence; Methadone; Pilot Projects; Vagus Nerve | - |
dc.title | Cardiac autonomic modulation during methadone therapy among heroin users: A pilot study | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.pnpbp.2012.01.006 | - |
dc.relation.pages | 188-193 | - |
dc.relation.journalvolume | 37 | - |
dc.relation.journalissue | 1 | - |
item.cerifentitytype | Publications | - |
item.fulltext | with fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | open | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.orcid | 0000-0001-7016-8990 | - |
crisitem.author.orcid | 0000-0003-0853-3904 | - |
crisitem.author.orcid | 0000-0003-0853-3904 | - |
crisitem.author.orcid | 0000-0001-7016-8990 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
Appears in Collections: | 醫學系
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