https://scholars.lib.ntu.edu.tw/handle/123456789/370129
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | WEI-TSO CHIA | en |
dc.creator | Chung, M.-F. and Chen, K.-J. and Liang, H.-F. and Liao, Z.-X. and Chia, W.-T. and Xia, Y. and Sung, H.-W. | - |
dc.date.accessioned | 2018-09-10T09:17:44Z | - |
dc.date.available | 2018-09-10T09:17:44Z | - |
dc.date.issued | 2012 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84866995252&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/370129 | - |
dc.description.abstract | Bubbling over: After endocytosis and intracellular trafficking to lysosomes, liposomes containing ammonium bicarbonate can be thermally triggered to generate CO2 bubbles (see scheme). These bubbles grow rapidly and collapse violently to induce transient cavitation, a process that can disrupt the lysosomal membrane and release lysosomal proteases, thus leading to cell necrosis. Copyright ? 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | - |
dc.language | en | en |
dc.relation.ispartof | Angewandte Chemie - International Edition | en_US |
dc.source | AH | - |
dc.subject | cancer; cavitation; cell necrosis; liposomes; vesicles | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Ammonium bicarbonates; cancer; Cell necrosis; Intracellular trafficking; Lysosomal membranes; Transient cavitation; vesicles; Ammonium compounds; Cavitation; Cell death; Enzyme activity; Liposomes; Molecular biology; Carbon dioxide; ammonium carbonate; carbon dioxide; carbonic acid derivative; article; cell survival; chemically induced disorder; drug delivery system; drug effect; flow cytometry; heat; human; lysosome; necrosis; pathology; tumor cell line; Carbon Dioxide; Carbonates; Cell Line, Tumor; Cell Survival; Drug Delivery Systems; Flow Cytometry; Hot Temperature; Humans; Lysosomes; Necrosis | - |
dc.title | A liposomal system capable of generating CO2 bubbles to induce transient cavitation, lysosomal rupturing, and cell necrosis | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/anie.201205482 | - |
dc.relation.pages | 10089-10093 | - |
dc.relation.journalvolume | 51 | - |
dc.relation.journalissue | 40 | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
crisitem.author.dept | Orthopedic Surgery-NTUHHC | - |
crisitem.author.orcid | 0000-0002-9357-2360 | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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