https://scholars.lib.ntu.edu.tw/handle/123456789/371811
標題: | Facile synthesis of highly emissive carbon dots from pyrolysis of glycerol; Gram scale production of carbon dots/mSiO 2 for cell imaging and drug release | 作者: | PI-TAI CHOU | 公開日期: | 2012 | 卷: | 22 | 期: | 29 | 起(迄)頁: | 14403-14409 | 來源出版物: | Journal of Materials Chemistry | 摘要: | We report on a facile method to synthesize carbon dots (CDs) using glycerol solvent as a single precursor via a pyrolysis process free from catalysts. This method is extremely simple and economical, and provides a feasible route for mass production of highly emissive CDs. For rationalization, a mechanism incorporating dehydration of glycerol, followed by acrylaldehyde formation is tentatively proposed for CD production. Further systematic improvement of particle homogeneity is made by harnessing the growth of CDs inside the mesoporous silica nanoparticles that act as a nano-reactor to regulate the size distribution. Simultaneously capping a polyethylene glycol (PEG)-derived reactant onto the CDs@SiO 2 enhances their luminescence, stability and bio-compatibility. The as-prepared CDs@mSiO 2-PEG nanocomposites are then loaded with the anti-cancer drug doxorubicin (DOX), so that the controlled release of DOX could be monitored by both time-dependent and spatially resolved ratiometric fluorescence intensity for CDs versus DOX in HeLa cells, successfully demonstrating that the CDs@mSiO 2-PEG nanocomposites are suitable for cell imaging and drug release. ? 2012 The Royal Society of Chemistry. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84863702610&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/371811 |
DOI: | 10.1039/c2jm32206d | SDG/關鍵字: | Anticancer drug; CdS; CdS@SiO; Cell imaging; Controlled release; Doxorubicin; Drug release; Facile method; Facile synthesis; Gram scale; HeLa cell; Mass production; Mesoporous silica nanoparticles; Pyrolysis process; Ratiometric fluorescence; Single precursors; Spatially resolved; Time-dependent; Glycerol; Nanocomposites; Polyethylene glycols; Carbon |
顯示於: | 化學系 |
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