https://scholars.lib.ntu.edu.tw/handle/123456789/378125
Title: | An initial evaluation of analyser-based phase-contrast X-ray imaging of carotid plaque microstructure | Authors: | Appel, A.A. CHENG-YING CHOU Larson, J.C. Zhong, Z. Schoen, F.J. Johnston, C.M. Brey, E.M. Anastasio, M.A. |
Issue Date: | 2013 | Journal Volume: | 86 | Journal Issue: | 1021 | Source: | British Journal of Radiology | Abstract: | Carotid artery plaque instability can result in rupture and lead to ischaemic stroke. Stability of plaques appears to be a function of composition. Current non-invasive imaging techniques are limited in their ability to classify distinct histological regions within plaques. Phase-contrast (PC) X-ray imaging methods are an emerging class of techniques that have shown promise for identifying soft-tissue features without use of exogenous contrast agents. This is the first study to apply analyser-based X-ray PC imaging in CT mode to provide three-dimensional (3D) images of excised atherosclerotic plaques. The results provide proof of principle for this technique as a promising method for analysis of carotid plaque microstructure. Multiple image radiography CT (MIR-CT), a tomographic implementation of X-ray PC imaging that employs crystal optics, was employed to image excised carotid plaques. MIR-CT imaging yields three complementary images of the plaque's 3D X-ray absorption, refraction and scatter properties. These images were compared with histological sections of the tissue. X-ray PC images were able to identify the interface between the plaque and the medial wall. In addition, lipid-rich and highly vascularized regions were visible in the images as well as features depicting inflammation. This preliminary research shows MIR-CT imaging can reveal details about plaque structure not provided by traditional absorption-based X-ray imaging and appears to identify specific histological regions within plaques. This is the first study to apply analyser-based X-ray PC imaging to human carotid artery plaques to identify distinct soft-tissue regions. ? 2013 The British Institute of Radiology. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84871860801&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/378125 |
DOI: | 10.1259/bjr.20120318 | SDG/Keyword: | artery calcification; article; carotid atherosclerosis; computed tomography scanner; computer assisted tomography; histology; human; human tissue; image quality; image reconstruction; in vivo study; light refraction; phase contrast X ray imaging; radiation absorption; three dimensional imaging; X ray; angiography; atherosclerosis; carotid artery disease; computer assisted tomography; equipment design; equipment failure analysis; instrumentation; pilot study; radiography; reproducibility; sensitivity and specificity; Angiography; Atherosclerosis; Carotid Artery Diseases; Equipment Design; Equipment Failure Analysis; Humans; Pilot Projects; Reproducibility of Results; Sensitivity and Specificity; Tomography, X-Ray Computed |
Appears in Collections: | 生物機電工程學系 |
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