https://scholars.lib.ntu.edu.tw/handle/123456789/378174
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Hu, C.-W. | en_US |
dc.contributor.author | Tseng, C.-W. | en_US |
dc.contributor.author | Chien, C.-W. | en_US |
dc.contributor.author | Huang, H.-C. | en_US |
dc.contributor.author | Ku, W.-C. | en_US |
dc.contributor.author | Lee, S.-J. | en_US |
dc.contributor.author | Chen, Y.-J. | en_US |
dc.contributor.author | Juan, H.-F. | en_US |
dc.creator | SHYH-JYE LEE;HSUEH-FEN JUAN;Juan, H.-F.;Chen, Y.-J.;Lee, S.-J.;Ku, W.-C.;Huang, H.-C.;Chien, C.-W.;Tseng, C.-W.;Hu, C.-W. | - |
dc.date.accessioned | 2018-09-10T09:44:30Z | - |
dc.date.available | 2018-09-10T09:44:30Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84883769174&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/378174 | - |
dc.description.abstract | MicroRNAs (miRNAs) are noncoding RNAs that control gene expression either by degradation of mRNAs or inhibition of protein translation. miR-148a has been reported to have the impacts on tumor progression. Here, a quantitative proteomics combined with stable isotope labeling was applied to identify the global profile of miR-148a-regulated downstream proteins. The data have been deposited to the ProteomeXchange with identifier PXD000190. A total of 2938 proteins were quantified, and 55 proteins were considered to be regulated by miR-148a. We found that not only proteins associated with cancer progression but also molecules involved in neural development were regulated by miR-148a. This study is the first to identify the function of miR-148a in neural development by using a proteomic approach. Analysis of a public clinical database also showed that the patients with neural diseases could display abnormal expression of miR-148a. Moreover, silencing of miR-148a led to the abnormal morphology and decreased expression of neuron-related markers in the developing brain of zebrafish. These results provided important insight into the regulation of neurological development elicited by miR-148a. ? 2013 American Chemical Society. | - |
dc.language | en | en |
dc.publisher | American Chemical Society | - |
dc.relation.ispartof | Journal of Proteome Research | en_US |
dc.source | AH | - |
dc.subject | iTRAQ; miR-148a; neurological development; proteome; zebrafish | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | microRNA; microRNA 148a; stable isotope; unclassified drug; animal model; article; cancer growth; cell line; chromatography; controlled study; DNA degradation; DNA flanking region; embryo; gene control; gene expression; gene function; gene silencing; genetic transfection; human; human cell; in vivo study; morphology; nervous system development; neurologic disease; nonhuman; priority journal; protein synthesis; proteomics; stomach cancer; tumor growth; wild type; zebra fish; Alzheimer Disease; Animals; Base Sequence; Brain; Case-Control Studies; Cell Line, Tumor; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Parkinson Disease; Proteomics; RNA Interference; Sequence Homology, Nucleic Acid; Spinal Cord; Stomach Neoplasms; Transcriptome; Zebrafish | - |
dc.title | Quantitative proteomics reveals diverse roles of mir-148a from gastric cancer progression to neurological development | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1021/pr400302w | - |
dc.relation.pages | 3993-4004 | - |
dc.relation.journalvolume | 12 | - |
dc.relation.journalissue | 9 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Life Science | - |
crisitem.author.dept | Center for Biotechnology | - |
crisitem.author.dept | Genome and Systems Biology Degree Program | - |
crisitem.author.dept | Developmental Biology and Regenerative Medicine | - |
crisitem.author.dept | Molecular and Cellular Biology | - |
crisitem.author.dept | Life Science | - |
crisitem.author.dept | Genome and Systems Biology Degree Program | - |
crisitem.author.dept | Office of Research and Development | - |
crisitem.author.orcid | 0000-0001-8452-9152 | - |
crisitem.author.orcid | 0000-0003-4876-3309 | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | Administrative Unit | - |
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