https://scholars.lib.ntu.edu.tw/handle/123456789/378620
標題: | Withanolide-based steroids from the cultured soft coral sinularia brassica | 作者: | Huang, C.-Y. Liaw, C.-C. Chen, B.-W. Chen, P.-C. Su, J.-H. Sung, P.-J. CHANG-FENG DAI Chiang, M.Y. Sheu, J.-H. |
公開日期: | 2013 | 卷: | 76 | 期: | 10 | 起(迄)頁: | 1902-1908 | 來源出版物: | Journal of Natural Products | 摘要: | Seven novel withanolides, sinubrasolides A-G (1-7), have been isolated from the cultured soft coral Sinularia brassica. The structures of the new metabolites were determined by extensive spectroscopic analyses, and the absolute configuration of 1 was established by X-ray crystallographic analysis. The cytotoxicities of compounds 1-7 against a limited panel of cancer cell lines also were determined. ? 2013 The American Chemical Society and American Society of Pharmacognosy. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84886835950&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/378620 |
DOI: | 10.1021/np400454q | SDG/關鍵字: | sinubrasolide A; sinubrasolide B; sinubrasolide C; sinubrasolide D; sinubrasolide E; sinubrasolide F; sinubrasolide G; unclassified drug; withanolide; article; cancer cell culture; carbon nuclear magnetic resonance; coral; drug acetylation; drug cytotoxicity; drug isolation; drug structure; nonhuman; proton nuclear magnetic resonance; Sinularia brassica; X ray crystallography; Animals; Anthozoa; Antineoplastic Agents; Crystallography, X-Ray; Drug Screening Assays, Antitumor; HT29 Cells; Humans; K562 Cells; Leukemia P388; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Withanolides |
顯示於: | 海洋研究所 |
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