https://scholars.lib.ntu.edu.tw/handle/123456789/380191
標題: | A CMOS wireless biomolecular sensing system-on-chip based on polysilicon nanowire technology | 作者: | Huang, C.-W. Huang, Y.-J. Yen, P.-W. Tsai, H.-H. Liao, H.-H. Juang, Y.-Z. Lu, S.-S. Lin, C.-T. SHEY-SHI LU CHIH-TING LIN |
公開日期: | 2013 | 卷: | 13 | 期: | 22 | 起(迄)頁: | 4451-4459 | 來源出版物: | Lab on a Chip - Miniaturisation for Chemistry and Biology | 摘要: | As developments of modern societies, an on-field and personalized diagnosis has become important for disease prevention and proper treatment. To address this need, in this work, a polysilicon nanowire (poly-Si NW) based biosensor system-on-chip (bio-SSoC) is designed and fabricated by a 0.35 μm 2-Poly-4-Metal (2P4M) complementary metal-oxide-semiconductor (CMOS) process provided by a commercialized semiconductor foundry. Because of the advantages of CMOS system-on-chip (SoC) technologies, the poly-Si NW biosensor is integrated with a chopper differential-difference amplifier (DDA) based analog-front-end (AFE), a successive approximation analog-to-digital converter (SAR ADC), and a microcontroller to have better sensing capabilities than a traditional Si NW discrete measuring system. In addition, an on-off key (OOK) wireless transceiver is also integrated to form a wireless bio-SSoC technology. This is pioneering work to harness the momentum of CMOS integrated technology into emerging bio-diagnosis technologies. This integrated technology is experimentally examined to have a label-free and low-concentration biomolecular detection for both Hepatitis B Virus DNA (10 fM) and cardiac troponin I protein (3.2 pM). Based on this work, the implemented wireless bio-SSoC has demonstrated a good biomolecular sensing characteristic and a potential for low-cost and mobile applications. As a consequence, this developed technology can be a promising candidate for on-field and personalized applications in biomedical diagnosis. ? 2013 The Royal Society of Chemistry. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84886056461&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/380191 |
DOI: | 10.1039/c3lc50798j | SDG/關鍵字: | metal oxide; nanowire; silicone; troponin I; virus DNA; amplifier; analog digital converter; article; biosensor; cost; Hepatitis B virus; lab on a chip; molecular diagnosis; nanotechnology; nonhuman; priority journal; semiconductor; wireless communication; Harness; Hepatitis B virus; Biosensing Techniques; DNA, Viral; Hepatitis B virus; Humans; Metals; Myocardium; Nanowires; Oxides; Semiconductors; Silicon; Temperature; Troponin I; Wireless Technology |
顯示於: | 電機工程學系 |
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