https://scholars.lib.ntu.edu.tw/handle/123456789/381019
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Hsu, P.-C. | en_US |
dc.contributor.author | Chen, P.-C. | en_US |
dc.contributor.author | Ou, C.-M. | en_US |
dc.contributor.author | Chang, H.-Y. | en_US |
dc.contributor.author | Chang, H.-T. | en_US |
dc.contributor.author | HUAN-TSUNG CHANG | zz |
dc.creator | Hsu, P.-C. | - |
dc.creator | Chen, P.-C. | - |
dc.creator | Ou, C.-M. | - |
dc.creator | Chang, H.-Y. | - |
dc.creator | Chang, H.-T. | - |
dc.date.accessioned | 2018-09-10T09:49:43Z | - |
dc.date.available | 2018-09-10T09:49:43Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84874834789&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/381019 | - |
dc.description.abstract | Highly water-soluble, biocompatible, and photoluminescent carbon nanodots (C-dots) having an average diameter 3.4 ± 0.8 nm and a quantum yield 4.3% are obtained from used green tea through grinding, calcination and centrifugation. The as-prepared C-dots are stable in high-ionic-strength media (e.g. 500 mM NaCl) and under light irradiation, allowing images of MCF-10A, MCF-7 and MDA-MB-231 cells to be recorded. The C-dots are mostly localized in the cell membranes and cytoplasms, with evidence of excitation-wavelength cell images. Relative to catechin, the C-dots provide greater inhibition efficiency of the growth of MCF-7 and MDA-MB-231 cancer cells, with lower toxicity for the MCF-10A normal cells. The inhibitory activity of C-dots is associated with the generation of greater amounts of reactive oxygen species. A prothrombin time (PT) assay of plasma samples reveals excellent biocompatibility of the C-dots. To the best of our knowledge, for the first time the C-dots provide inhibition efficiencies up to 80% and 82% for MCF-7 and MDA-MB-231 cancer cells, respectively, showing their high potential as cancer inhibitors. ? The Royal Society of Chemistry 2013. | - |
dc.language | en | en |
dc.relation.ispartof | Journal of Materials Chemistry B | en_US |
dc.source | AH-Scopus to ORCID | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Average diameter; Inhibition activity; Inhibition efficiency; Inhibitory activity; Light irradiations; Mda-mb-231 cells; Prothrombin time; Reactive oxygen species; Biocompatibility; Calcination; Cell membranes; Centrifugation; Cytology; Ionic strength; Carbon | - |
dc.title | Extremely high inhibition activity of photoluminescent carbon nanodots toward cancer cells | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1039/c3tb00545c | - |
dc.identifier.scopus | 2-s2.0-84874834789 | - |
dc.identifier.isi | WOS:000315722500001 | - |
dc.relation.pages | 1774-1781 | - |
dc.relation.journalvolume | 1 | - |
dc.relation.journalissue | 13 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Chemistry | - |
crisitem.author.orcid | 0000-0002-5393-1410 | - |
crisitem.author.parentorg | College of Science | - |
顯示於: | 化學系 |
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