https://scholars.lib.ntu.edu.tw/handle/123456789/382856
Title: | Impairment of gastrointestinal quality of life in severely obese patients | Authors: | PO-JUI YU | Keywords: | Gastro-intestinal symptoms; Glycosylated hemoglobin; Quality of life; Severe obesity | Issue Date: | 2014 | Journal Volume: | 20 | Journal Issue: | 22 | Start page/Pages: | 7027-7033 | Source: | World Journal of Gastroenterology | Abstract: | Aim: To investigate the common gastro-intestinal symptoms and quality of life in severely obese subjects. Methods: We prospectively recruited 340 severely obese patients [mean age 30.5 ± 7.8 years; mean body mass index (BMI) 42.9 ± 6.1 kg/m2] and 340 healthy persons (mean BMI 23.1 ± 3.8 kg/m2) matched in sex, age, marriage and education. The quality of life was studied using a specific gastrointestinal quality of life index (GIQLI) questionnaire. The 36 items and four functional domains of the GIQLI were compared and analyzed between the groups. The possible correlation of GIQLI scores with specific clinical variables in severely obese patients was assessed by measuring Pearson's coefficient of correlation. Results: The mean GIQLI score of severely obese patients was lower than the normal control group (108.5 ± 17.1 vs 123.2 ± 14.8, P < 0.01). Severely obese patients had decreased scores in the domains of general health, including physical (17.3 ± 6.0 vs 22.4 ± 3.1, P < 0.01), emotional (12.6 ± 4.3 vs 16.6 ± 3.1, P < 0.01) and social function (14.7 ± 3.9 vs 17.9 ± 2.5, P < 0.01), and in the domain of gastrointestinal symptoms (63.9 ± 6.7 vs 66.3 ± 7.2, P < 0.05). A significantly decreased score was found in nine items, and there was an increased score in one out of the 19 items in the domain of symptoms of the GIQLI questionnaire. The decreased score in the domain of symptoms was correlated with increasing glycosylated hemoglobin (HbA1c) levels. Conclusion: Severe obesity resulted in a significant impairment of the quality of life and caused specific gastrointestinal symptoms compared with normal controls. The development of gastrointestinal symptoms is correlated increasing HbA1c, suggesting that a poor control of hyperglycemia might be the etiology. ? 2014 Baishideng Publishing Group Inc. All rights reserved. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84902136645&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/382856 |
DOI: | 10.3748/wjg.v20.i22.7027 | SDG/Keyword: | antidiabetic agent; antihypertensive agent; antilipemic agent; hemoglobin A1c; biological marker; glycosylated hemoglobin; hemoglobin A1c protein, human; adult; article; body mass; controlled study; defecation; diarrhea; diet restriction; emotional stability; female; gastroesophageal reflux; gastrointestinal symptom; heartburn; human; hyperglycemia; hypertension; incontinence; major clinical study; male; metabolic syndrome X; non insulin dependent diabetes mellitus; obesity; prospective study; quality of life; questionnaire; social status; blood; case control study; complication; cost of illness; emotion; Gastrointestinal Diseases; hyperglycemia; obesity; psychology; risk factor; severity of illness index; social behavior; young adult; Adult; Biological Markers; Case-Control Studies; Cost of Illness; Emotions; Female; Gastrointestinal Diseases; Hemoglobin A, Glycosylated; Humans; Hyperglycemia; Male; Obesity; Prospective Studies; Quality of Life; Questionnaires; Risk Factors; Severity of Illness Index; Social Behavior; Young Adult |
Appears in Collections: | 護理學系所 |
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