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Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/383233
Title: The effect of hyperoxia on survival following adult cardiac arrest: A systematic review and meta-analysis of observational studies
Authors: Lin, Keh-chung
CHIH-HUNG WANG
Wang, Chih-Hung
Chang, Wei-Tien
Wang, Tien-ni
CHIEN-HUA HUANG
Wu, Ching-yi
WEI-TIEN CHANG
Huang, Chien-Hua
Tsai, Min-Shan
Chen, Chia-ling
MIN-SHAN TSAI
Chang, Kai-chieh
Yu, Ping-Hsun
WEN-JONE CHEN
Lin, Yu-chan
Wang, An-Yi
Chen, Yi-ju
Chen, Nai-Chuan
LIN, KEH-CHUNG
WANG, TIEN-NI
Chen, Wen-Jone
WU, CHING-YI
CHEN, CHIA-LING
CHANG, KAI-CHIEH
LIN, YU-CHAN
Lin, Keh-chung
CHIH-HUNG WANG
Wang, Chih-Hung
Chang, Wei-Tien
Wang, Tien-ni
CHIEN-HUA HUANG
Wu, Ching-yi
WEI-TIEN CHANG
Huang, Chien-Hua
Tsai, Min-Shan
Chen, Chia-ling
MIN-SHAN TSAI
Chang, Kai-chieh
Yu, Ping-Hsun
WEN-JONE CHEN
Lin, Yu-chan
Wang, An-Yi
Chen, Yi-ju
Chen, Nai-Chuan
LIN, KEH-CHUNG
WANG, TIEN-NI
Chen, Wen-Jone
WU, CHING-YI
CHEN, CHIA-LING
CHANG, KAI-CHIEH
LIN, YU-CHAN
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Issue Date: 2014
Journal Volume: 85
Journal Issue: 9
Start page/Pages: 1142-1148
Source: Resuscitation 
Abstract: 
Objective: Studies have shown the detrimental effect of hyperoxia in animals with return of spontaneous circulation (ROSC) after cardiac arrest. To maximize the value of existing clinical studies, we performed the systemic review and meta-analysis of human observational studies to examine the effect of hyperoxia on outcomes of post-ROSC patients. Methods: We searched PubMed and Embase from the inception to October 2013. We selected adult observational studies that compared different levels of partial pressure of arterial oxygen (PaO2) in post-ROSC patients with mortality or neurological status at hospital discharge as outcome. Studies comparing hypoxia with normoxia only were excluded. Results: Fourteen studies were identified from 2982 references. Odds ratio (OR) was used as effect estimate. OR was reconstructed if not provided in original articles. Hyperoxia was defined as a PaO2 >300mmHg. Meta-analysis indicated that hyperoxia appeared to be correlated with increased in-hospital mortality (OR, 1.40; 95% CI, 1.02-1.93; I2, 69.27%; 8 studies) but not worsened neurological outcome (OR, 1.62; 95% CI, 0.87-3.02; I2, 55.61%; 2 studies). However, the results were inconsistent in subgroup and sensitivity analyses. Conclusions: Hyperoxia appears to be correlated with increased in-hospital mortality of post-ROSC patients. This result should be interpreted cautiously because of the significant heterogeneity and limited number of studies analyzed. However, because exposure to hyperoxia had no obvious benefits, clinicians should monitor PaO2 closely and titrate oxygen administration cautiously. ? 2014 Elsevier Ireland Ltd.
URI: http://www.scopus.com/inward/record.url?eid=2-s2.0-84906047413&partnerID=MN8TOARS
http://scholars.lib.ntu.edu.tw/handle/123456789/383233
DOI: 10.1016/j.resuscitation.2014.05.021
metadata.dc.subject.other: carbon dioxide; oxygen; adult disease; arterial carbon dioxide tension; arterial oxygen tension; cardiac patient; disease severity; heart arrest; heart ventricle fibrillation; hospital discharge; human; hyperoxia; intensive care; meta analysis; oxygenation; priority journal; return of spontaneous circulation; review; survival; systematic review; cardiovascular mortality; functional status; nonhuman; observational study; outcome assessment; oxygen therapy; resuscitation; Review; sensitivity analysis; survival; adult; complication; heart arrest; hyperoxia; mortality; survival rate; Adult; Heart Arrest; Hospital Mortality; Humans; Hyperoxia; Observational Studies as Topic; Survival Rate
[SDGs]SDG3
Appears in Collections:醫學系

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