https://scholars.lib.ntu.edu.tw/handle/123456789/385765
標題: | Persistent endocrine disruption effects in medaka fish with early life-stage exposure to a triazole-containing aromatase inhibitor (letrozole) | 作者: | Liao, P.-H. Chu, S.-H. Tu, T.-Y. Wang, X.-H. Lin, A.Y.C. Chen, P.-J. PEI-JEN CHEN ANGELA YU-CHEN LIN |
關鍵字: | Aromatase inhibitor; Cytochrome P450 (CYP); Letrozole; Medaka (Oryzias latipes) | 公開日期: | 2014 | 卷: | 277 | 起(迄)頁: | 141-149 | 來源出版物: | Journal of Hazardous Materials | 摘要: | Letrozole (LET) is a triazole-containing drug that can inhibit the activity of cytochrome P450 aromatase. It is an environmentally emerging pollutant because of its broad use in medicine and frequent occurrence in aquifers receiving the effluent of municipal or hospital wastewater. However, the toxic impact of LET on fish populations remains unclear. We exposed medaka fish (Oryzias latipes) at an early stage of sexual development to a continuous chronic LET at environmentally relevant concentrations and assessed the endocrine disruption effects in adulthood and the next generation. LET exposure at an early life stage persistently altered phenotypic sex development and reproduction in adults and skewed the sex ratio in progeny. As well, LET exposure led to a gender-different endocrine disruption as seen by the interruption in gene expression responsible for estrogen synthesis and metabolism and fish reproduction. LET interfering with the aromatase system in early life stages of medaka can disrupt hormone homeostasis and reproduction. This potent aromatase inhibitor has potential ecotoxicological impact on fish populations in aquatic environments. © 2014 Elsevier B.V. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84903772689&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/385765 |
DOI: | 10.1016/j.jhazmat.2014.02.013 | SDG/關鍵字: | Aquifers; Effluents; Fish; Fisheries; Gene expression; Groundwater pollution; Hydrogeology; Living systems studies; Nitrogen compounds; Aquatic environments; Aromatase inhibitors; Cytochrome p450; Emerging pollutants; Endocrine disruption; Hospital wastewater; Letrozole; Oryzias latipes; Endocrine disrupters; endocrine disruptor; letrozole; aromatase inhibitor; endocrine disruptor; letrozole; nitrile; triazole derivative; water pollutant; adult; aquatic environment; biological development; concentration (composition); cytochrome; drug; ecotoxicology; endocrine disruptor; enzyme activity; fish; gene expression; pollution exposure; population genetics; sex ratio; toxic substance; wastewater; adult; adulthood; aquatic environment; article; controlled study; embryo; environmental exposure; estrogen metabolism; estrogen synthesis; female; gender; gene expression; male; nonhuman; Oryzias latipes; reproduction; sex ratio; sexual development; animal; animal embryo; drug effects; growth, development and aging; larva; metabolism; Oryzias; sexual maturation; toxicity; water pollutant; Oryzias latipes; Oryziinae; Animals; Aromatase Inhibitors; Embryo, Nonmammalian; Endocrine Disruptors; Larva; Nitriles; Oryzias; Sexual Maturation; Triazoles; Water Pollutants, Chemical |
顯示於: | 農業化學系 |
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