|Title:||Health-related quality of life and cost comparison of adjuvant capecitabine versus 5-fluorouracil/leucovorin in stage III colorectal cancer patients||Authors:||MING-CHIN YANG||Keywords:||Adjuvant treatment; Colorectal cancer; Quality of life; Societal cost||Issue Date:||2014||Journal Volume:||24||Journal Issue:||2||Start page/Pages:||473-484||Source:||Quality of Life Research||Abstract:||
Purpose: The purpose of this study was to compare health-related quality of life (HRQoL) and costs associated with 2 adjuvant chemotherapy regimens [capecitabine-based therapy versus 5-fluorouracil/leucovorin (5-FU/LV)-based therapy] in stage III colorectal cancer patients. Methods: We conducted a prospective, open-label, observational, multicenter study from July 2008 to July 2011. The European Organization for Research and Treatment of Cancer QLQ-C30 and QLQ-CR38 questionnaires was used to assess HRQoL before, during, and after treatment. The direct and indirect costs of adjuvant treatment were estimated from a specially prepared questionnaire, the National Health Insurance Research Database, and other published sources. We used propensity scoring to match samples between groups and performed multivariate analyses to adjust for differences in patient demographics and clinical characteristics. Results: A total of 497 patients were enrolled, and 356 completed the surveys. Following propensity score matching, 239 patients were included in the analysis (122 in the capecitabine-based group, 117 in the 5-FU/LV-based group). Global HRQoL scores did not differ significantly between the two groups. However, compared to patients in the 5-FU/LV-based group, patients in the capecitabine-based group had less nausea and vomiting (mid-term, P?=?0.024; final, P?=?0.013), appetite loss (mid-term, P?0.0001; final, P?=?0.001), and fewer side effects from chemotherapy (mid-term, P?=?0.017). In addition, the monthly cost of capecitabine-based therapy was lower than those of 5-FU/LV-based therapy [NT$31,895.46 (US$1063.18) vs. NT$79,159.24 (US$2638.64) per patient]. Conclusions: Capecitabine is a reasonable alternative and cost-effective treatment option under current conditions for patients with stage III colorectal cancer. ? 2014, Springer International Publishing Switzerland.
|DOI:||10.1007/s11136-014-0773-x||metadata.dc.subject.other:||antineoplastic agent; antineoplastic antimetabolite; capecitabine; deoxycytidine; fluorouracil; folinic acid; adjuvant chemotherapy; adult; aged; analogs and derivatives; clinical trial; Colorectal Neoplasms; cost benefit analysis; economics; female; health status; human; male; middle aged; multicenter study; pathology; prospective study; quality of life; questionnaire; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Cost-Benefit Analysis; Deoxycytidine; Female; Fluorouracil; Health Status; Humans; Leucovorin; Male; Middle Aged; Prospective Studies; Quality of Life; Questionnaires
|Appears in Collections:||公共衛生學系|
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