https://scholars.lib.ntu.edu.tw/handle/123456789/390199
Title: | Decreased serum level of lipoprotein cholesterol is a poor prognostic factor for patients with severe community-acquired pneumonia that required intensive care unit admission | Authors: | Chong-Jen Yu CHUNG-YU CHEN CHIA-LIN HSU KUAN-YU CHEN CHONG-JEN YU |
Issue Date: | 2015 | Journal Volume: | 30 | Journal Issue: | 3 | Start page/Pages: | 506-510 | Source: | Journal of Critical Care | Abstract: | Purpose: The purpose of this study is to investigate the prognostic values of the serum levels of lipids in patients with severe community-acquired pneumonia (CAP) that required intensive care unit (ICU) admission. Materials and methods: Patients who had severe CAP that required ICU admission were included. Serum lipid level was collected on the days 1 and 7 of ICU stay. Clinical outcome, including length of ICU stay, hospital stay, and death, were monitored prospectively. Results: A total of 40 patients were enrolled in this study. Lower high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were found in nonsurvival group on ICU admission day 7 (survivors vs nonsurvivors; mean HDL, 41.8 vs 13.0 mg/dL, P = .002; LDL, 62.3 vs 30.3 mg/dL, P = 0.006, respectively). High-density lipoprotein cholesterol level of less than or equal to 17 mg/dL on day 7 (odds ratio, 1.23) and LDL cholesterol level of less than or equal to 21 mg/dL on day 7 (odds ratio, 1.10) could be a predictor of hospital mortality. The mean change in levels of HDL cholesterol in nonsurvivors decreased significantly than those in survivors from days 1 to 7 (8.5 vs -. 17.4 mg/dL, P = .04) but not LDL cholesterol. Conclusions: Decreased serum HDL cholesterol level from days 1 to 7 may be of prognostic value. ? 2015 Elsevier Inc. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84928583153&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/390199 |
DOI: | 10.1016/j.jcrc.2015.01.001 | SDG/Keyword: | high density lipoprotein cholesterol; lipid; lipoprotein; low density lipoprotein cholesterol; high density lipoprotein cholesterol; low density lipoprotein cholesterol; adult; Article; cholesterol blood level; clinical article; community acquired pneumonia; controlled study; disease severity; female; hospital admission; hospitalization; human; intensive care unit; length of stay; lipid blood level; lipoprotein blood level; male; mortality; prognosis; prospective study; aged; blood; cohort analysis; community acquired infection; disease course; middle aged; pneumonia; very elderly; Aged; Aged, 80 and over; Cholesterol, HDL; Cholesterol, LDL; Cohort Studies; Community-Acquired Infections; Disease Progression; Female; Hospital Mortality; Humans; Intensive Care Units; Length of Stay; Male; Middle Aged; Pneumonia; Prognosis; Prospective Studies |
Appears in Collections: | 醫學系 |
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