https://scholars.lib.ntu.edu.tw/handle/123456789/390222
Title: | Gastroprotective potential against indomethacin and safety assessment of the homology of medicine and food formula cuttlebone complex | Authors: | FU-CHUO PENG | Issue Date: | 2015 | Journal Volume: | 6 | Journal Issue: | 8 | Start page/Pages: | 2803-2812 | Source: | Food and Function | Abstract: | Cuttlebone complex (CBC), a homology of medicine and food formula, is comprised of five herbal medicines (Endoconcha Sepiae, Radix Paeoniae Rubra, fresh ginger, Fructus Amomi, and Radix Glycyrrhizae) and two food ingredients (Zingiber zerumbet and chitosan). Herein, the gastroprotective potential against indomethacin and a safety assessment of CBC were investigated. In a gastroprotective model, CBC effectively decreased the indomethacin-increased gastric ulcerous lesions, and increased the indomethacin-decreased prostaglandin E2 levels in the gastric mucosa. In genotoxicity tests, CBC treatment did not increase the numbers of revertant colonies in five Salmonella typhimurium strains and chromosome aberrations in Chinese hamster ovary CHO-K1 cells, with or without S9 metabolic activation. The oral supplementation of CBC did not increase micronucleus formation in the peripheral blood of mice. In a subacute toxicity study, the body weight and blood biochemical parameters observed in CBC-treated rats were normal. In conclusion, CBC was considered as a non-toxic formula and could be used to remedy indomethacin-induced gastric damage. ? The Royal Society of Chemistry. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84938820245&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/390222 |
DOI: | 10.1039/c5fo00638d | SDG/Keyword: | Blood; Chromosomes; Food additives; Mammals; Safety engineering; Salmonella; Biochemical parameters; Chinese hamster ovary; Chromosome aberration; Food ingredients; Metabolic activation; Prostaglandin E2; Safety assessments; Salmonella typhimurium; Food safety; Cricetulus griseus; Mus; Rattus; Salmonella typhimurium; Zingiber officinale; Zingiber zerumbet; indometacin; plant extract; protective agent; adverse effects; animal; chemically induced; chemistry; CHO cell line; Cricetulus; drug effects; gastric mucosa; hamster; human; Institute for Cancer Research mouse; male; medicinal plant; mouse; mutagen testing; rat; Sprague Dawley rat; stomach ulcer; Animals; CHO Cells; Cricetinae; Cricetulus; Gastric Mucosa; Humans; Indomethacin; Male; Mice; Mice, Inbred ICR; Mutagenicity Tests; Plant Extracts; Plants, Medicinal; Protective Agents; Rats; Rats, Sprague-Dawley; Stomach Ulcer |
Appears in Collections: | 毒理學研究所 |
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