https://scholars.lib.ntu.edu.tw/handle/123456789/390363
Title: | L-carnitine ameliorates dyslipidemic and hepatic disorders induced by a high-fat diet via regulating lipid metabolism, self-antioxidant capacity, and inflammatory response | Authors: | Su, Chang-Chao Chang, Chaung-Sung CHUNG-HSI CHOU Wu, Yi-Hsieng Samuel Yang, Kuo-Tai Tseng, Jung-Kai Chang, Yuan-Yen YI-CHEN CHEN |
Keywords: | Antioxidant effect; High-fat diet; L-carnitine; Lipid homeostasis; Non-alcoholic fatty liver disease; Serum lipid | Issue Date: | 2015 | Journal Volume: | 15 | Start page/Pages: | 497-508 | Source: | Journal of Functional Foods | Abstract: | The cardiovascular and liver protection of carnitine (CNT) in a high-fat diet was investigated. Male C57BL/6 mice were divided randomly into four groups: 1) CON: Control, 2) HFD: high-fat diet, 3) CNTL: HFD + 500 mg CNT/kg BW, and 4) CNTH: HFD + 1500 mg CNT/kg BW. After a 25-week experimental period, CNT supplementation reduced (p < 0.05) serum triacylglycerol (TAG), cholesterol (TC) and LDLC/HDLC ratio, and liver TAG contents. CNT supplementation downregulated (p < 0.05) gene expressions of lipogenesis, but upregulated (p < 0.05) gene expressions of cholesterol clearance/catabolism and energy expenditure. Serum trolox equivalent antioxidants capacity (TEAC), and liver glutathione (GSH) contents and glutathione-peroxidase (GPx) activity of HFD fed mice were also increased (p < 0.05) by CNT supplementation. Besides, proinflammation related gene expressions (Tlr4 and Nfκb) and proinflammatory cytokine (TNF-α) contents in livers of HFD fed mice were also decreased (p < 0.05) by CNT supplementation. Furthermore, in comparison with the ameliorative effects of two-dosage CNT treatments on dyslipidemic and hepatic disorders induced by a high-fat diet, low dosage of CNT seems more effective than high dosage of CNT. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84929243558&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/390363 |
DOI: | 10.1016/j.jff.2015.04.007 |
Appears in Collections: | 動物科學技術學系 |
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