https://scholars.lib.ntu.edu.tw/handle/123456789/390456
標題: | A selective decoy-doxorubicin complex for targeted co-delivery, STAT3 probing and synergistic anti-cancer effect | 作者: | Wang, S.-J. YUNG-TE HOU LIN-CHI CHEN |
公開日期: | 2015 | 卷: | 51 | 期: | 68 | 起(迄)頁: | 13309-13312 | 來源出版物: | Chemical Communications | 摘要: | A novel selective decoy oligodeoxynucleotide (dODN)-doxorubicin (DOX) complex is reported for cancer theranostics. It eliminates the use of a ligand or carrier for targeted delivery and disassembles into therapeutic dODN and DOX upon encountering over-activated STAT3 in cancer cells. Hence, in situ STAT3 probing and synergistic anti-cancer effect are attained at the same time. ? 2015 Royal Society of Chemistry. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84938917594&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/390456 |
DOI: | 10.1039/c5cc04435a | SDG/關鍵字: | aptamer; bovine serum albumin; doxorubicin; lipofectamine; oligodeoxynucleotide; quantum dot; STAT3 protein; streptavidin; antineoplastic agent; doxorubicin; drug carrier; fluorescent dye; lipid; oligodeoxyribonucleotide; STAT3 protein; STAT3 protein, human; antineoplastic activity; apoptosis; Article; binding affinity; binding competition; cancer cell; cell death; circular dichroism; competitive binding assay; drug potentiation; drug release; fluorescence microscopy; liposomal delivery; malignant neoplastic disease; MCF 7 cell line; protein binding; ultraviolet spectroscopy; antagonists and inhibitors; chemistry; HepG2 cell line; human; theranostic nanomedicine; Antineoplastic Agents; Doxorubicin; Drug Carriers; Fluorescent Dyes; Hep G2 Cells; Humans; Lipids; MCF-7 Cells; Oligodeoxyribonucleotides; STAT3 Transcription Factor; Theranostic Nanomedicine |
顯示於: | 生物機電工程學系 |
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