https://scholars.lib.ntu.edu.tw/handle/123456789/391082
Title: | Krill oil and xanthigen separately inhibit high fat diet induced obesity and hepatic triacylglycerol accumulation in mice | Authors: | Lee, M.-F. Lai, C.-S. Cheng, A.-C. Hou, J.-S. Badmaev, V. Ho, C.-T. MIN-HSIUNG PAN |
Keywords: | High-fat diet; Krill oil; Non-alcoholic fatty liver disease; Obesity; Steatosis; Xanthigen | Issue Date: | 2015 | Journal Volume: | 19 | Start page/Pages: | 913-921 | Source: | Journal of Functional Foods | Abstract: | Krill oil (KO) is rich in omega-3 long-chain polyunsaturated fatty acids, eicosapentaenoic acid and docosahexaenoic acid. Previous studies have shown that KO supplementation alleviated hepatic steatosis in rodents. Xanthigen (brown marine algae fucoxanthin + pomegranate seed oil) is an important source of fucoxanthin and punicic acid. Our recent work indicated that xanthigen (Xan) significantly suppressed 3T3-L1 preadipocyte differentiation and lipid accumulation. Here we investigated the effect of KO and Xan on lipid accumulation in HepG2 liver cancer cells and on high fat diet (HFD)-induced obesity in C57BL/6J mice. KO potently inhibited triacylglycerol accumulation in Hep G2 cells. Supplementation with 2.5% KO or Xan effectively reduced HFD-induced body weight gain and adipose mass increase without affecting food intake, and improved diet-induced hepatic steatosis. In summary, KO and Xan may act as novel agents for the treatment of diet-induced obesity and steatosis. © 2014 Elsevier Ltd. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84948716756&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/391082 |
DOI: | 10.1016/j.jff.2014.10.015 |
Appears in Collections: | 食品科技研究所 |
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