https://scholars.lib.ntu.edu.tw/handle/123456789/391089
標題: | Antitumor Activity of Garcinol in Human Prostate Cancer Cells and Xenograft Mice | 作者: | Wang, Y. Tsai, M.-L. Chiou, L.-Y. Ho, C.-T. Pan, M.-H. MIN-HSIUNG PAN |
關鍵字: | apoptosis; autophagy; garcinol; prostate cancer cells and xenograft mice | 公開日期: | 2015 | 卷: | 63 | 期: | 41 | 起(迄)頁: | 9047-9052 | 來源出版物: | Journal of Agricultural and Food Chemistry | 摘要: | Garcinol, which is isolated from fruit rinds of Garcinia indica, is a polyisoprenylated benzophenone. It has been studied for its antitumor activity by inducing apoptosis and inhibiting autophagy in human prostate cancer cells. The Bax/Bcl-2 ratio increased when garcinol was applied to PC-3 cells indicating a presence of apoptosis. Meanwhile, procaspases-9 and -3 were suppressed with attenuating PARP and DFF-45. Autophagy was inhibited through activating p-mTOR and p-PI3 Kinase/AKT by garcinol, which as a result induced the cells to apoptosis directly. In addition, the apoptosis effect of garcinol in a xenograft mouse model was also tested, suggesting a consistent result with PC-3 cell model. The tumor size was reduced more than 80 percent after the mouse accepted the garcinol treatment. Garcinol was demonstrated to have a strong antitumor activity through inhibiting autophagy and inducing apoptosis, which was discovered for the first time. Based on these findings, our data suggests that garcinol deserves further investigation as a potent chemopreventive agent. ? 2015 American Chemical Society. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84945157596&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/391089 |
DOI: | 10.1021/acs.jafc.5b03851 | SDG/關鍵字: | Biological materials; Cell death; Cytology; Diseases; Mammals; Urology; Anti-tumor activities; Autophagy; Chemopreventive agents; Garcinia indica; garcinol; Human prostate cancer cells; Mouse models; Prostate cancer cells; Cells; antineoplastic agent; DNA fragmentation factor, human; garcinol; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; protein; protein bcl 2; terpene; animal; chemistry; drug screening; Garcinia; genetics; human; male; metabolism; mouse; pathophysiology; Prostatic Neoplasms; tumor cell line; Animals; Antineoplastic Agents; Cell Line, Tumor; Garcinia; Humans; Male; Mice; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; Proteins; Proto-Oncogene Proteins c-bcl-2; Terpenes; Xenograft Model Antitumor Assays |
顯示於: | 食品科技研究所 |
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