https://scholars.lib.ntu.edu.tw/handle/123456789/393912
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Fu S.-C. | en_US |
dc.contributor.author | Huang Y.-W. | en_US |
dc.contributor.author | Wang T.-C. | en_US |
dc.contributor.author | Hu J.-T. | en_US |
dc.contributor.author | DING-SHINN CHEN | en_US |
dc.contributor.author | Yang S.-S. | en_US |
dc.creator | Fu, S.-C. and Huang, Y.-W. and Wang, T.-C. and Hu, J.-T. and Chen, D.-S. and Yang, S.-S. | - |
dc.date.accessioned | 2018-09-10T15:24:42Z | - |
dc.date.available | 2018-09-10T15:24:42Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84929132837&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/393912 | - |
dc.description.abstract | Background Diabetes increases the risk of hepatocellular carcinoma (HCC), however, the time-relationship between hepatitis B virus and diabetes for the development of HCC remains unclear. Aim To explore the risk of HCC in chronic hepatitis B patients with newly diagnosed diabetes. Methods We conducted a nationwide cohort study by using Taiwanese National Health Insurance Research Database, which covers over 99% of entire population. Among randomly sampled one million enrollees, 14 523 chronic hepatitis B patients were diagnosed in years 1997-2009. We defined new onset diabetes as patients who were given the diagnosis in the years 1999-2009, but not in 1997-1998. The cohorts of chronic hepatitis B with new onset diabetes (n = 2099) and 1:1 ratio age-, gender-and inception point (onset date of diabetes)-matched nondiabetes (n = 2080) were followed up from the inception point until development of HCC, withdrawal from insurance or December 2009. Results After adjustment for competing mortality, patients with new onset diabetes had a significantly higher cumulative incidence of HCC [relative risk = 1.628, 95% confidence interval (CI) = 1.114-2.378, modified log-rank test, P = 0.012] as compared to nondiabetes patients. After adjustment for age, gender, hyperlipidaemia, chronic hepatitis B treatment, statins therapy, cirrhosis, comorbidity index and obesity, diabetes was still an independent predictor for HCC (hazard ratio = 1.798, 95% CI = 1.194-2.707, P = 0.005). Conclusion Chronic hepatitis B patients with newly diagnosed diabetes have an increased risk of hepatocellular carcinoma over time. ? 2015 John Wiley & Sons Ltd. | en_US |
dc.language | en | en |
dc.relation.ispartof | Alimentary Pharmacology and Therapeutics | en_US |
dc.source | AH-Scopus to ORCID | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | hydroxymethylglutaryl coenzyme A reductase inhibitor; adult; age; aged; Article; cancer incidence; cancer risk; chronic hepatitis B; cohort analysis; comorbidity; controlled study; diabetes mellitus; disease association; female; follow up; human; hyperlipidemia; liver cell carcinoma; liver cirrhosis; longitudinal study; major clinical study; male; middle aged; mortality; obesity; priority journal; sex difference; very elderly; Carcinoma, Hepatocellular; complication; diabetes mellitus; hepatitis B; Hepatitis B virus; incidence; isolation and purification; Liver Neoplasms; risk; virology; young adult; Adult; Aged; Aged, 80 and over; Carcinoma, Hepatocellular; Cohort Studies; Diabetes Mellitus; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Incidence; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Risk; Young Adult | - |
dc.title | Increased risk of hepatocellular carcinoma in chronic hepatitis B patients with new onset diabetes: A nationwide cohort study | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/apt.13191 | - |
dc.relation.pages | 1200-1209 | en_US |
dc.relation.journalvolume | 41 | en_US |
dc.relation.journalissue | 11 | en_US |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0001-7791-6154 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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