https://scholars.lib.ntu.edu.tw/handle/123456789/394158
標題: | Unibody core-shell smart polymer as a theranostic nanoparticle for drug delivery and MR imaging | 作者: | Ho, L.-C. Hsu, C.-H. Ou, C.-M. Wang, C.-W. Liu, T.-P. Hwang, L.-P. Lin, Y.-Y. Chang, H.-T. HUAN-TSUNG CHANG |
關鍵字: | Core-shell; Drug delivery; Magnetic resonance imaging (MRI); Nanoparticle | 公開日期: | 2015 | 卷: | 37 | 起(迄)頁: | 436-446 | 來源出版物: | Biomaterials | 摘要: | Developing novel multifunctional nanoparticles (NPs) with robust preparation, low cost, high stability, and flexible functionalizability is highly desirable. This study provides an innovative platform, termed unibody core-shell (UCS), for this purpose. UCS is comprised of two covalent-bonded polymers differed only by the functional groups at the core and the shell. By conjugating Gd3+ at the stable core and encapsulating doxorubicin (Dox) at the shell in a pH-sensitive manner, we developed a theranostic NPs (UCS-Gd-Dox) that achieved a selective drug release (75% difference between pH 7.4 and 5.5) and MR imaging (r1=0.9 and 14.5mm-1s-1 at pH 7.4 and 5.5, respectively). The anti-cancer effect of UCS-Gd-Dox is significantly better than free Dox in tumor-bearing mouse models, presumably due to enhanced permeability and retention effect and pH-triggered release. To the best of our knowledge, this is the simplest approach to obtain the theranostic NPs with Gd-conjugation and Dox doping. ? 2014 Elsevier Ltd. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84922225204&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/394158 |
DOI: | 10.1016/j.biomaterials.2014.10.006 | SDG/關鍵字: | Controlled drug delivery; Drug delivery; Magnetic resonance imaging; Nanomagnetics; Nanoparticles; Polymers; Shells (structures); Core shell; Drug release; Enhanced Permeability and Retention effect; Magnetic Resonance Imaging (MRI); Multi-functional nanoparticles; pH sensitive; Smart polymers; Triggered release; Targeted drug delivery; doxorubicin; gadolinium; polymer; unclassified drug; unibody core shell polymer; nanoparticle; polymer; animal experiment; antineoplastic activity; Article; controlled study; drug delivery system; drug penetration; drug release; encapsulation; female; human; human cell; mouse; nonhuman; nuclear magnetic resonance imaging; pH; priority journal; 3T3 cell line; animal; diagnostic use; HeLa cell line; nonobese diabetic mouse; SCID mouse; time; ultrastructure; Animals; Drug Delivery Systems; Female; Gadolinium; HeLa Cells; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Imaging; Mice; Mice, Inbred NOD; Mice, SCID; Nanoparticles; NIH 3T3 Cells; Polymers; Time Factors |
顯示於: | 化學系 |
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