https://scholars.lib.ntu.edu.tw/handle/123456789/395001
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | LI-JIUAN SHEN | en_US |
dc.contributor.author | Lin, Shu-Chiao | en_US |
dc.contributor.author | Huang, Chih-Fen | en_US |
dc.contributor.author | CHIH-FEN HUANG | en_US |
dc.contributor.author | Shen, Li-Jiuan | en_US |
dc.contributor.author | Wang, Hsueh-Ju | en_US |
dc.contributor.author | Chen, Min-Huey | en_US |
dc.contributor.author | Lin, Chia-Yu | en_US |
dc.contributor.author | Wu, Fe-Lin Lin | en_US |
dc.creator | Lin, S.-C.;Huang, C.-F.;Shen, L.-J.;Wang, H.-J.;Lin, C.-Y.;Wu, F.L.L.Lin, Shu-Chiao;Huang, Chih-Fen;Shen, Li-Jiuan;Wang, Hsueh-Ju;Lin, Chia-Yu;Wu, Fe-Lin Lin | - |
dc.date.accessioned | 2018-09-10T15:26:47Z | - |
dc.date.available | 2018-09-10T15:26:47Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84983179915&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/395001 | - |
dc.description.abstract | Background/Purpose: Acanthamoeba keratitis is difficult to treat because Acanthamoeba cysts are resistant to the majority of antimicrobial agents. Despite the efficacy of 0.02% chlorhexidine in treating Acanthamoeba keratitis, a lack of data in the literature regarding the formulation's stability limits its clinical use. The objective of this study was to develop an optimal extemporaneous 0.02% chlorhexidine digluconate ophthalmic formulation for patients in need. Methods: With available active pharmaceutical ingredients, 0.02% chlorhexidine digluconate sample solutions were prepared by diluting with BSS Plus Solution or acetate buffer. Influences of the buffer, type of container, and temperature under daily-open condition were assessed based on the changes of pH values and chlorhexidine concentrations of the test samples weekly. To determine the beyond-use date, the optimal samples were stored at 2-8°C or room temperature, and analyzed at time 0 and at Week 1, Week 2, Week 3, Week 4, Week 5, Week 8, Week 12, and Week 24. Results: Despite chlorhexidine exhibiting better stability in acetate buffer than in BSS solution, its shelf-life was < 14 days when stored in a light-resistant low-density polyethylene container. The acetate-buffered 0.02% chlorhexidine digluconate solution stored in light-resistant high-density polyethylene eyedroppers did not exhibit significant changes in pH or strength at any time interval. Conclusion: The acetate-buffered 0.02% chlorhexidine digluconate ophthalmic solution stored in light-resistant high-density polyethylene eyedroppers demonstrated excellent stability at 2-25°C for 6 months after being sealed and for 1 month after opening. This finding will enable us to prepare 0.02% chlorhexidine digluconate ophthalmic solutions based on a doctor's prescription. ? 2014. | en_US |
dc.language | en | en |
dc.relation.ispartof | Journal of the Formosan Medical Association | en_US |
dc.source | AH-Scopus to ORCID | - |
dc.subject | Compatibility; Dosage forms; Drug compounding; Infectious disease; Ophthalmology; Pharmaceutics | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | acetic acid; balanced salt solution; buffer; chlorhexidine gluconate; eye drops; chlorhexidine; chlorhexidine gluconate; eye drops; Acanthamoeba keratitis; Article; drug formulation; drug stability; human; osmolality; particulate matter; personal experience; pH; quality control; room temperature; shelf life; analogs and derivatives; drug stability; standards; time factor; Acanthamoeba Keratitis; Chlorhexidine; Drug Compounding; Drug Stability; Humans; Ophthalmic Solutions; Time Factors | - |
dc.title | Formulation and stability of an extemporaneous 0.02% chlorhexidine digluconate ophthalmic solution | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jfma.2014.08.003 | - |
dc.relation.pages | 1162 | en_US |
dc.relation.journalvolume | 114 | en_US |
dc.relation.journalissue | 12 | en_US |
dc.relation.pageend | 1169 | en_US |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Office of International Affairs | - |
crisitem.author.dept | Pharmacy | - |
crisitem.author.dept | Pharmacy-NTUH | - |
crisitem.author.dept | School of Pharmacy | - |
crisitem.author.dept | Pharmacy | - |
crisitem.author.dept | Pharmacy-NTUH | - |
crisitem.author.dept | School of Pharmacy | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Office of International Affairs | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Pharmacy | - |
crisitem.author.orcid | 0000-0002-2854-3205 | - |
crisitem.author.orcid | 0000-0003-1311-8828 | - |
crisitem.author.orcid | 0000-0003-1311-8828 | - |
crisitem.author.orcid | 0000-0002-2854-3205 | - |
crisitem.author.orcid | 0000-0002-5813-1172 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | Administrative Unit | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | Administrative Unit | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
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