https://scholars.lib.ntu.edu.tw/handle/123456789/398633
Title: | Comparative Outcome Analysis of Penicillin-Based Versus Fluoroquinolone-Based Antibiotic Therapy for Community-Acquired Pneumonia | Authors: | Wang, Chi-Chuan WANG-HUEI SHENG CHI-CHUAN WANG Lin, Chia-Hui Lin, Kuan-Yin YU-CHUNG CHUANG Chuang, Yu-Chung Sheng, Wang-Huei |
Issue Date: | 2016 | Journal Volume: | 95 | Journal Issue: | 6 | Source: | Medicine (United States) | Abstract: | Community-Acquired pneumonia (CAP) is a common but potentially life-Threatening condition, but limited information exists on the effectiveness of fluoroquinolones compared to β-lactams in outpatient settings. We aimed to compare the effectiveness and outcomes of penicillins versus respiratory fluoroquinolones for CAP at outpatient clinics. This was a claim-based retrospective cohort study. Patients aged 20 years or older with at least 1 new pneumonia treatment episode were included, and the index penicillin or respiratory fluoroquinolone therapies for a pneumonia episode were at least 5 days in duration. The 2 groups were matched by propensity scores. Cox proportional hazard models were used to compare the rates of hospitalizations/emergence service visits and 30-day mortality. A logistic model was used to compare the likelihood of treatment failure between the 2 groups. After propensity score matching, 2622 matched pairs were included in the final model. The likelihood of treatment failure of fluoroquinolone-based therapy was lower than that of penicillin-based therapy (adjusted odds ratio [AOR], 0.88; 95% confidence interval [95%CI], 0.77-0.99), but no differences were found in hospitalization/emergence service (ES) visits (adjusted hazard ratio [HR], 1.27; 95% CI, 0.92-1.74) and 30-day mortality (adjusted HR, 0.69; 95% CI, 0.30-1.62) between the 2 groups. The likelihood of treatment failure of fluoroquinolone-based therapy was lower than that of penicillin-based therapy for CAP on an outpatient clinic basis. However, this effect may be marginal. Further investigation into the comparative effectiveness of these 2 treatment options is warranted. Copyright ? 2016 Wolters Kluwer Health, Inc. All rights reserved. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84958260200&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/398633 |
DOI: | 10.1097/MD.0000000000002763 | metadata.dc.subject.other: | antiinfective agent; penicillin derivative; quinolone derivative; adult; aged; cohort analysis; Community-Acquired Infections; comparative study; female; human; male; middle aged; Pneumonia, Bacterial; retrospective study; Taiwan; treatment outcome; very elderly; young adult; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Cohort Studies; Community-Acquired Infections; Female; Fluoroquinolones; Humans; Male; Middle Aged; Penicillins; Pneumonia, Bacterial; Retrospective Studies; Taiwan; Treatment Outcome; Young Adult [SDGs]SDG3 |
Appears in Collections: | 醫學系 |
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