https://scholars.lib.ntu.edu.tw/handle/123456789/399596
標題: | Oral Ulcers as an Initial Presentation of Juvenile Pemphigus: A Case Report | 作者: | LI-FANG WANG | 關鍵字: | oral ulcers; paraneoplastic pemphigus; pemphigus vulgaris; rituximab | 公開日期: | 2016 | 卷: | 57 | 期: | 4 | 起(迄)頁: | 338-342 | 來源出版物: | Pediatrics and Neonatology | 摘要: | Pemphigus vulgaris (PV) is an autoimmune disease in which the autoantibody, immunoglobulin G, is directed against the keratinocytes in the epidermis. The classic presentations of PV are flaccid vesicles or bullae over the oral mucosa, trunk, groin, and extremities. The age of onset is usually between 40 and 60 years, and cases of PV in children or adolescent patients are rare. Here, we present a 17-year-old boy who had painful oral ulcers for 3 months initially and bullae spreading to the whole body in the following days. Paraneoplastic pemphigus was another differential diagnosis due to the atypical appearance of the skin lesion. However, PV was confirmed by hematoxylin and eosin staining and immunofluorescence examination of the skin biopsy specimens. The patient had a good response to corticosteroid treatment and the immunosuppressive agent, rituximab. ? 2013 |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84888325406&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/399596 |
DOI: | 10.1016/j.pedneo.2013.08.008 | SDG/關鍵字: | aciclovir; analgesic agent; C reactive protein; immunoglobulin; immunoglobulin G; local anesthetic agent; methylprednisolone; oxacillin; prednisolone; rituximab; corticosteroid; immunosuppressive agent; acantholysis; adolescent; Article; bacterial infection; case report; chickenpox; computer assisted tomography; corticosteroid therapy; coughing; differential diagnosis; eosinophilia; erythrocyte sedimentation rate; fatigue; hand foot and mouth disease; histopathology; human; human tissue; keratinocyte; lung infiltrate; male; mouth ulcer; mucosa inflammation; multiple cycle treatment; nutritional status; paraneoplastic pemphigus; pemphigus; pemphigus vulgaris; secondary infection; skin biopsy; thorax radiography; underweight; Varicella zoster virus; weight reduction; complication; Oral Ulcer; pemphigus; Adolescent; Adrenal Cortex Hormones; Diagnosis, Differential; Humans; Immunosuppressive Agents; Male; Oral Ulcer; Pemphigus |
顯示於: | 醫學系 |
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