https://scholars.lib.ntu.edu.tw/handle/123456789/400862
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | YU-KANG TU | en_US |
dc.contributor.author | PO-YAUN SHIH | en_US |
dc.contributor.author | YU-CHANG YEH | en_US |
dc.contributor.author | Chang T. | en_US |
dc.contributor.author | Shih P.-Y. | en_US |
dc.contributor.author | ANNE CHAO | en_US |
dc.contributor.author | HSING-HAO HUANG | en_US |
dc.contributor.author | YA-JUNG CHENG | en_US |
dc.contributor.author | Yeh Y.-C. | en_US |
dc.contributor.author | Behalf of the NTUH Center of Microcirculation Medical Research (NCMMR) | en_US |
dc.creator | Lee, C.-T. ; Tu, Y.-K. ;Yeh, Y.-C. ; Chang, T. ;Shih, P.-Y. ; Chao, A. ;Huang, H.-H. ; Cheng, Y.-J. ; Yeh, Y.-C. | - |
dc.date.accessioned | 2018-09-10T18:03:25Z | - |
dc.date.available | 2018-09-10T18:03:25Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-85037644257&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/400862 | - |
dc.description.abstract | Purpose We designed this study to examine the clinical effects of polymyxin B hemoperfusion (PMX-HP) in septic shock patients. Material and methods We retrospectively examined the effects of PMX-HP in septic shock patients with intra-abdominal or gram-negative bacterial infection during October 2013–May 2016. A one-to-one matching between the PMX-HP and conventional groups was performed, and 28-day mortality, and change in inotropic score, Sequential Organ Failure Assessment (SOFA) score, and Acute Physiology and Chronic Health Evaluation II (APACHE II) score at 24 h in the two groups were compared. In addition, multivariable regression analysis and Cox proportional hazards regression model were applied in all eligible patients. Results Sixty-nine patients were eligible, of whom fifty patients were enrolled for matched cohort analysis. In matched cohort analysis, change in inotropic score after 24 h (? 24.8 [19.7] vs. ? 6.4 [20.0], p = 0.002) differed significantly between the PMX-HP and conventional groups. Multivariable regression analysis revealed that PMX-HP was associated with lower 28-day mortality (odds ratio 0.18, 95% CI 0.04–0.92, p = 0.039) and greater improvement in inotropic and APACHE II scores. Conclusions PMX-HP may have potential benefits for hemodynamic and prognostic outcomes in septic shock patients with intra-abdominal or gram-negative bacterial infection. ? 2017 | en_US |
dc.language | en | en |
dc.relation.ispartof | Journal of Critical Care | en_US |
dc.source | AH-Scopus to ORCID | - |
dc.subject | Abdominal infection; Endotoxin; Gram-negative bacteria; Polymyxin B hemoperfusion; Septic shock | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | polymyxin B; antiinfective agent; polymyxin B; abdominal infection; adult; aged; APACHE; Article; cohort analysis; controlled study; drug effect; female; Gram negative infection; hemodynamics; hemoperfusion; human; major clinical study; male; mortality; prognosis; retrospective study; septic shock; Sequential Organ Failure Assessment Score; treatment outcome; clinical trial; Gram negative infection; hemoperfusion; multicenter study; organ dysfunction score; prognosis; septic shock; Taiwan; Aged; Anti-Bacterial Agents; APACHE; Cohort Studies; Female; Gram-Negative Bacterial Infections; Hemoperfusion; Humans; Male; Organ Dysfunction Scores; Polymyxin B; Prognosis; Retrospective Studies; Shock, Septic; Taiwan | - |
dc.title | Effects of polymyxin B hemoperfusion on hemodynamics and prognosis in septic shock patients | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jcrc.2017.04.035 | - |
dc.relation.pages | 202-206 | en_US |
dc.relation.journalvolume | 43 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Institute of Health Data Analytics and Statistics | - |
crisitem.author.dept | Master of Public Health Degree Program | - |
crisitem.author.dept | Anesthesiology-NTUH | - |
crisitem.author.dept | Anesthesiology-NTUH | - |
crisitem.author.dept | Anesthesiology | - |
crisitem.author.dept | Anesthesiology-NTUH | - |
crisitem.author.dept | Anesthesiology | - |
crisitem.author.dept | Anesthesiology-NTUH | - |
crisitem.author.dept | Anesthesiology-NTUH | - |
crisitem.author.dept | Anesthesiology | - |
crisitem.author.orcid | 0000-0002-2461-474X | - |
crisitem.author.orcid | 0000-0002-1096-9179 | - |
crisitem.author.orcid | 0000-0001-5143-5520 | - |
crisitem.author.orcid | 0000-0002-7170-3817 | - |
crisitem.author.orcid | 0000-0002-0919-4644 | - |
crisitem.author.orcid | 0000-0001-9150-4690 | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 流行病學與預防醫學研究所 |
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