https://scholars.lib.ntu.edu.tw/handle/123456789/401297
Title: | Perfluoroalkyl substance exposure and urine CC16 levels among asthmatics: A case-control study of children | Authors: | YUNG-LING LEE | Keywords: | Asthma; Biomarkers; CC16; Interaction; Perfluoroalkyl substances | Issue Date: | 2017 | Journal Volume: | 159 | Start page/Pages: | 158-163 | Source: | Environmental Research | Abstract: | Background Studies have reported an association between serum perfluoroalkyl substances (PFASs) and asthma. However, few studies have examined the possible associations between PFASs and the 16-kDa club cell secretory protein (Clara) (CC16) level, a prominent biomarker of asthma, among adolescents. Methods We recruited a total of 231 asthmatic children and 225 non-asthmatic controls in the Genetic and Biomarkers study for Childhood Asthma (GBCA) in northern Taiwan from 2009 to 2010. Structured questionnaires were administered by face-to-face interview. Urine CC16 was determined by an enzyme-link immunoassay kit. Multiple general linear models were employed to examine the associations between PFASs and urinary CC16 levels. Results Asthmatic participants had significantly higher serum PFAS concentrations overall than the healthy controls. After adjusting for confounding factors, urinary CC16 was significantly, negatively associated with PFASs, especially PFOS, PFOA, PFDA and PFNA, and especially among males, as follows: PFOS (β = ?0.003, 95% confidence interval [CI]: ?0.004, ?0.002), PFOA (β = ?0.045, 95% CI: ?0.086, ?0.004), and PFHxA (β = ?0.310, 95% CI: ?0.455, ?0.165) among asthmatic boys, and PFDA (β = ?0.126, 95%CI: ?0.241, ?0.012) and PFNA (β = ?0.329, 95% CI: ?0.526, ?0.132) among non-asthmatic boys. Among girls, PFDA (β = ?0.088, 95% CI: ?0.172, ?0.004), was the only PFAS significantly associated with CC16. Significant interaction effects (p < 0.15) on CC16 levels were found between asthma and PFOS, PFOA, PFBS and PFHxA in all participants. Conclusion Our overall results showed that serum PFASs were significantly, inversely associated with CC16 levels. Associations were stronger among males. ? 2017 Elsevier Inc. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-85026922999&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/401297 |
DOI: | 10.1016/j.envres.2017.08.005 | SDG/Keyword: | biological marker; club cell secretory protein cc16; peptides and proteins; perfluoroalkanoic acid; perfluorodecanoic acid; perfluorononanoic acid; perfluorooctanesulfonic acid; perfluorooctanic acid; unclassified drug; alkanesulfonic acid; fluorocarbon; pollutant; SCGB1A1 protein, human; uteroglobin; asthma; biomarker; chemical substance; child health; confidence interval; immunoassay; pollution exposure; questionnaire survey; urine; adolescent; Article; asthma; child; controlled study; environmental exposure; enzyme linked immunosorbent assay; female; human; major clinical study; male; priority journal; structured questionnaire; Taiwan; urine; asthma; blood; case control study; genetics; metabolism; pollutant; Taiwan; Adolescent; Alkanesulfonic Acids; Asthma; Case-Control Studies; Child; Environmental Exposure; Environmental Pollutants; Female; Fluorocarbons; Humans; Male; Taiwan; Uteroglobin |
Appears in Collections: | 流行病學與預防醫學研究所 |
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