https://scholars.lib.ntu.edu.tw/handle/123456789/401298
標題: | Rapid adiposity growth increases risks of new-onset asthma and airway inflammation in children | 作者: | YUNG-LING LEE | 公開日期: | 2017 | 卷: | 41 | 期: | 7 | 起(迄)頁: | 1035-1041 | 來源出版物: | International Journal of Obesity | 摘要: | Background/Objectives:We aim to (1) examine the influence of long-term adiposity status/short-term adiposity changes on asthma with high or low fractional exhaled nitric oxide (Fe NO), and (2) to determine the differences in long-term adiposity status/short-term adiposity changes on atopy, airway inflammation and pulmonary function.Subjects/Methods:We recruited 2450 fourth-to sixth-grade children from the nationwide Taiwan Children Health Study. Data regarding various adiposity indicators, atopic status, pulmonary function tests and asthma outcomes were collected annually. New-onset asthma was stratified by airway inflammation status using Fe NO. The generalized estimating equation was used for analyzing longitudinal relationships between long-term adiposity status/short-term adiposity changes and new-onset asthma. Individual adiposity growth slopes were obtained using a hierarchical linear model to establish the relationships between short-term adiposity changes and asthma among children with high airway inflammation.Results:We found long-term adiposity status predicted childhood asthma with low Fe NO, whereas short-term adiposity changes may increase risks of childhood asthma with high Fe NO. Long-term adiposity status reduced pulmonary function, whereas short-term adiposity increase were associated with atopic diseases and airway inflammation.Conclusions:Obesity-induced asthma could be mediated by high or low airway inflammation, depending on the velocity of increase in adiposity. Rapid adiposity growth may increase risks of childhood asthma and airway inflammation. ? 2017 Macmillan Publishers Limited, part of Springer Nature. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-85016973212&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/401298 |
DOI: | 10.1038/ijo.2017.67 | SDG/關鍵字: | fractional exhaled nitric oxide; nitric oxide; unclassified drug; nitric oxide; allergic conjunctivitis; allergic rhinitis; Article; asthma; atopic dermatitis; atopy; body fat; body mass; body weight; child; childhood obesity; female; human; lung function; lung function test; major clinical study; male; priority journal; respiratory tract inflammation; risk factor; school child; Taiwan; waist circumference; waist hip ratio; waist to height ratio; adolescent; asthma; body weight loss; breath analysis; childhood obesity; comorbidity; complication; epidemiology; exercise; exhalation; fitness; forced expiratory volume; immunology; inflammation; interdisciplinary communication; longitudinal study; obesity; pathophysiology; physiology; Adiposity; Adolescent; Asthma; Body Mass Index; Breath Tests; Child; Comorbidity; Exercise; Exhalation; Female; Forced Expiratory Volume; Humans; Inflammation; Interdisciplinary Communication; Longitudinal Studies; Male; Nitric Oxide; Pediatric Obesity; Physical Fitness; Taiwan; Weight Loss |
顯示於: | 流行病學與預防醫學研究所 |
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