|Title:||Analysis of experience-regulated transcriptome and imprintome during critical periods of mouse visual system development reveals spatiotemporal dynamics||Authors:||Chi-Lin Hsu
Ivan Pochou Lai
Neil A Youngson
Susan Shur-Fen Gau
|Issue Date:||Jan-2018||Publisher:||OXFORD UNIV PRESS||Journal Volume:||27||Journal Issue:||6||Start page/Pages:||1039–1054||Source:||HUMAN MOLECULAR GENETICS||Abstract:||
Visual system development is light-experience dependent, which strongly implicates epigenetic mechanisms in lightregulated maturation. Among many epigenetic processes, genomic imprinting is an epigenetic mechanism through which monoallelic gene expression occurs in a parent-of-origin-specific manner. It is unknown if genomic imprinting contributes to visual system development. We profiled the transcriptome and imprintome during critical periods of mouse visual system development under normal-and dark-rearing conditions using B6/CAST F1 hybrid mice. We identified experience-regulated, isoform-specific and brain-region-specific imprinted genes. We also found imprinted microRNAs were predominantly clustered into the Dlk1-Dio3 imprinted locus with light experience affecting some imprinted miRNA expression. Our findings provide the first comprehensive analysis of light-experience regulation of the transcriptome and imprintome during critical periods of visual system development. Our results may contribute to therapeutic strategies for visual impairments and circadian rhythm disorders resulting from a dysfunctional imprintome. © The Author(s) 2018. Published by Oxford University Press. All rights reserved.
|Appears in Collections:||腦與心智科學研究所|
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