|Title:||ABO genotyping with next-generation sequencing to resolve heterogeneity in donors with serology discrepancies||Authors:||Wu, Ping Chun
Tsai, Lei Fang
Chen, Ming Hung
|Issue Date:||2018||Publisher:||WILEY||Source:||Transfusion||Journal Volume:||58||Journal Issue:||9||Start page/Pages:||2232||Abstract:||
ABO subtypes are characterized by the alteration of antigens present and their expression levels on red blood cells and many are linked to genetic changes in the ABO gene. Weakened expression of antigens should be identified to prevent transfusion reactions or ABO-incompatible transplantations. Genotyping can be applied to identify subtypes to complement serologic testing. Next-generation sequencing (NGS) has shown to provide sensitive and accurate genotyping results as well as valuable cis/trans information. Here we took advantage of NGS and applied it to resolve serology discrepancies in ABO typing.
|Appears in Collections:||基因體暨蛋白體醫學研究所|
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