https://scholars.lib.ntu.edu.tw/handle/123456789/406780
標題: | Reduction in Cholesterol and Sialic Acid Content Protects Cells from the Toxic Effects of £]-Amyloid Peptides | 作者: | Wang S.S.-S. Rymer D.L. Good T.A. |
公開日期: | 2001 | 卷: | 276 | 期: | 45 | 起(迄)頁: | 42027-42034 | 來源出版物: | Journal of Biological Chemistry | 摘要: | £]-Amyloid (A£]) is the primary protein component of senile plaques associated with Alzheimer's disease and has been implicated in the neurotoxicity associated with the disease. A variety of evidence points to the importance of A£]-membrane interactions in the mechanism of A£] neurotoxicity and indicates that cholesterol and gangliosides are particularly important for A£] aggregation and binding to membranes. We investigated the effects of cholesterol and sialic acid depletion on A£]-induced GTPase activity in cells, a step implicated in the mechanism of A£] toxicity, and A£]-induced cell toxicity. Cholesterol reduction and depletion of membrane-associated sialic acid residues both significantly reduced the A£]-induced GTPase activity. In addition, cholesterol and membrane-associated sialic acid residue depletion or inhibition of cholesterol and ganglioside synthesis protected PC12 cells from A£]-induced toxicity. These results indicate the importance of A£]-membrane interactions in the mechanism of A£] toxicity. In addition, these results suggest that control of cellular cholesterol and/or ganglioside content may prove useful in the prevention or treatment of Alzheimer's disease. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/406780 | ISSN: | 00219258 | DOI: | 10.1074/jbc.M102834200 |
顯示於: | 化學工程學系 |
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