https://scholars.lib.ntu.edu.tw/handle/123456789/408139
標題: | Supramolecular Assembly Mediates the Formation of Single-Chain Polymeric Nanoparticles | 作者: | Cheng C.-C. Chang F.-C. Yen H.-C. Lee D.-J. Chiu C.-W. Xin Z. |
公開日期: | 2015 | 卷: | 4 | 期: | 10 | 起(迄)頁: | 1184-1188 | 來源出版物: | ACS Macro Letters | 摘要: | A breakthrough innovation in water-based polymeric nanoparticles has enabled significant progress in mimicking the folding of natural proteins by generating novel "single-chain polymeric nanoparticles" (SCPNs) via supramolecular interactions. In this study, a practical approach to the living polymerization of functionalized oligo(ethylene glycol) methacrylate monomers allows the incorporation of self-constituted multiple hydrogen-bonded groups into physically cross-linked polymer networks, which enables the formation of highly functionalized SCPNs in an aqueous environment. The newly developed materials are particularly attractive from a practical point of view since they have a very low critical micellization concentration and uniform particle diameters of ca. 25 nm, making them extremely stable under dilute conditions. Concentration-dependent experiments showed that SCPNs formed at polymer concentrations up to 40 mg/mL with no significant change in morphology observed. Moreover, the formed SCPNs had a very high stability in an aqueous solution containing surfactant, suggesting potential for a wide variety of applications as a promising candidate nanocarrier for bioimaging, controlled release, and drug delivery systems. ? 2015 American Chemical Society. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/408139 | ISSN: | 21611653 | DOI: | 10.1021/acsmacrolett.5b00556 |
顯示於: | 化學工程學系 |
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