https://scholars.lib.ntu.edu.tw/handle/123456789/408850
標題: | Superparamagnetic Gadolinium Ferrite Nanoparticles with Controllable Curie Temperature ¡V Cancer Theranostics for MR-Imaging-Guided Magneto-Chemotherapy | 作者: | Thorat N.D. Bohara R.A. Tofail S.A.M. Alothman Z.A. Shiddiky M.J.A. A Hossain M.S. Yamauchi Y. Wu K.C.-W. |
關鍵字: | Gadolinium;Imaging agents;Magnetic properties;Nanoparticles | 公開日期: | 2016 | 卷: | 2016 | 期: | 28 | 起(迄)頁: | 4586-4597 | 來源出版物: | European Journal of Inorganic Chemistry | 摘要: | A facile polyol approach for preparing low-Curie-temperature (T C ) gadolinium-doped iron oxide nanoparticles (GdIO NPs) for targeted magnetic hyperthermia and chemotherapy coupled with T 1 ¡VT 2 dual-model magnetic resonance (MR) imaging (where T 1 and T 2 are the longitudinal and transverse relaxation times, respectively) is reported. A small amount of Gd doping decreases the T C of iron oxide down to about 400 K. In the presence of ethanolamine, controlled polyol synthesis leads to the formation of low-T C , highly magnetic (52.87 emu g ¡V1 ), and size-controlled (ca. 10 nm) GdIO NPs. A further conjugation with folate and a chemotherapeutic drug has been developed, and the whole system is used for in vitro magneto-chemotherapy (magnetic hyperthermia and chemotherapy) for cancer treatment. The synthesized GdIO NPs are stable colloids that are hemocompatible and cytocompatible over a wide concentration range and have a high affinity towards cancer cells. The release of a chemotherapeutic drug from the GdIO NPs significantly affects cancer cell viability, and the T 1 ¡VT 2 dual-model magnetic resonance enhances bioimaging in a breast cancer cell model. We suggest that the chemotherapeutic-drug-conjugated GdIO NPs have great potential for cell targeting and magnetic resonance imaging in cancer magneto-chemotherapy. ? 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/408850 | ISSN: | 14341948 | DOI: | 10.1002/ejic.201600706 |
顯示於: | 化學工程學系 |
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