https://scholars.lib.ntu.edu.tw/handle/123456789/409672
標題: | Modeling the physiological glucose-insulin system on normal and diabetic subjects | 作者: | Chen C.-L. Tsai H.-W. |
關鍵字: | Delay differential equations (DDEs);Glucose-insulin system;Human endocrinology;Parametric estimation;Physiology | 公開日期: | 2010 | 卷: | 97 | 期: | 2 | 起(迄)頁: | 130-140 | 來源出版物: | Computer Methods and Programs in Biomedicine | 摘要: | This paper aims to present a mathematical model to describe the plasma glucose and insulin daily variations on normal and diabetic subjects. The proposed model consists of two delay differential equations (DDEs) where five adjustable parameters are used to characterize the respective dynamics and oscillation behavior of normal and diabetic subjects. Several clinical data tests demonstrate that the suggested model is practical to approach the daily-life glucose dynamics on normal, diabetic Type 1 and Type 2 subjects. Moreover, the corresponding parameters are fairly persuasive to identify the patients' conditions of physiological functions. ? 2009 Elsevier Ireland Ltd. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/409672 | ISSN: | 01692607 | DOI: | 10.1016/j.cmpb.2009.06.005 | SDG/關鍵字: | Adjustable parameters; Clinical data; Delay differential equations; Delay differential equations (DDEs); Human endocrinology; Oscillation behavior; Parametric estimation; Physiological functions; Physiological glucose; Plasma glucose; Two delays; Differential equations; Endocrinology; Estimation; Glucose; Insulin; Mathematical models; Physiological models; glucose; insulin; article; blood glucose monitoring; daily life activity; diabetes mellitus; diagnostic accuracy; endocrine function; endocrine system examination; glucose blood level; glucose insulin system; human; insulin blood level; insulin dependent diabetes mellitus; insulin release; mathematical model; molecular dynamics; non insulin dependent diabetes mellitus; oscillation; pathophysiology; Computer Simulation; Diabetes Mellitus; Dietary Carbohydrates; Glucose; Humans; Hyperglycemia; Insulin; Metabolic Clearance Rate; Models, Biological; Pancreas |
顯示於: | 化學工程學系 |
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