https://scholars.lib.ntu.edu.tw/handle/123456789/40992
標題: | 巴金森病人之情緒功能:長期追蹤研究(III) | 作者: | 花茂棽 | 關鍵字: | 情緒狀態;巴金森病;單氨類化學物質失調;Emotional Status;Parkinson’s Disease;Monoaminergic Imbalance | 公開日期: | 2003 | 出版社: | 臺北市:國立臺灣大學心理學系暨研究所 | 摘要: | 巴金森病是一種常見中樞神經系統的退化疾病。運動障礙、認知功能缺損、以及情緒功能失調,特別憂鬱問題是主要的症狀。但是文獻上所呈現這類患者罹患憂鬱與焦慮問題的盛行率,卻是不大一致。本研究計劃以三年的時間,利用追蹤方式來探討這個爭議未決的問題。完成第三年研究計劃,總共收集到192 位成年受試參與本研究,其中包括127 位巴金森患者和65 位正常受試。依照侯-葉氏(Hoehn-Yahr,1967)運動障礙評量表127 患者中,58 位屬於第一級輕度運動障礙、52 位第二級輕中度運動障礙、以及18 位第三級中度運動障礙.。每一位受試都分別接受一組認知功能之神經心理測驗,以及一組情緒功能之測量。受試之主要照顧者同時也接受一組情緒功能之測量。完成第一年追蹤研究之受試者總共53 人;其中21 人屬於第一級輕度運動障礙、17 位第二級輕中度運動障礙、9 位第三級中度運動障礙,以及正常受試者6 位。完成第二年追蹤研究之受試者總共22 人;其中4 人屬於第一級輕度運動障礙、3 位第二級輕中度運動障礙、5 位第三級中度運動障礙,以及正常受試者10 位。 初步資料分析之結果顯示巴金森病患呈現情緒功能失調的問題。主要包括了憂鬱、焦慮、身心不適、強迫性行為等症狀。大約40%的巴金森患有憂鬱的問題;第一級輕度運動障礙患者有43%患有這種情緒症狀、第二級輕中度運動障礙患者有30%、第三級中度運動障礙患者有50%。這三組巴金森病患中約有55%罹患失智症狀群,不過只有40%的這些失智患者同時出現憂鬱症狀。完成第一年追蹤研究之患者中,約有32%呈現憂鬱問題。第一級輕度運動障礙患者有24%、第二級輕中度運動障礙患者有35%、第三級中度運動障礙患者有44%這種情緒症狀。憂鬱症狀程度達到重憂鬱症(major depressive disorder)約有15%;其中第一級 輕度運動障礙患者約15%、第二級輕中度運動障礙患者18%、第三級中度運動障礙患者11%出現該疾患。完成第一年追蹤研究之患者中約有64%罹患失智症狀群。完成第二年追蹤研究之患者中,約有50%呈現憂鬱問題。第一級輕度運動障礙患者有50%、第二級輕中度運動障礙患者有100%、第三級中度運動障礙患者有33%這種情緒症狀。憂鬱症狀程度達到重憂鬱症(major depressive disorder)約有33%;其中第一級輕度運動運動障礙患者約50%、第二級輕中度運動障礙患者0%、第三級中度運動障礙患者33%出現該疾患。完成第二年追蹤研究之患者中約有40%罹患失智症狀群,不過只有50%的這些失智症患者同時出現憂鬱症狀。 Parkinson’s disease (PD) is a prevailing degenerative disease of central nervous system. Motor symptoms, cognitive impairments including dementia, and emotional disturbances, especially depression are the cardinal features of the disease. The prevalence rate of depression and anxiety in the parkinsonian patients has a great variation. The present 3-year follow-up study, thus, is designed to examine emotional function in these patients. In this third-year study, we included a total of 192 adult participants, 127 patients with idiopathic PD and 65 normal controls. On the basis of the motor staging of Hoehn and Yahr (1967), Group 1 consisted of 58 patients with the staging I, Group 2 included 52 patients with the staging II, and Group 3 were composed of 18 patients with the staging III. Each subject received a series of non-emotional neuropsychological test battery, and emotional status measures. The significant informant of each subject also received a series of emotional function measures. 53 patients completed the first-year follow-up. Among these, 21 of them were rated as the staging I in terms of their motor disabilities; 17 the staging II; and 9 the staging III, as well as 6 normal counterparts. 22 of these subjects have received the second-year follow-up. Among them, 4 patients were rated as the staging I of Hoehn-Yahr Scale, 3 the staging II, and 5 the staging III, as well as 10 of normal control subjects. Because of a high dropout rate, only 6 out of 12 patients completed the 2nd-year follow-up of emotional status examination. The preliminary results revealed that about 50% of our patients manifested depression symptom. Among them, 50% of patients with staging I, 100% with staging II, and 33% with staging III were evident of this symptom. About 33% suffered from Major Depressive Disorder in which 50%, 0%, and 33% with the motor stagings I-III respectively had this disorder. About 40% of our patients suffered from the syndrome of dementia based on the demented diagnostic criteria of the DSM-IV. However, about 50% of these demented patients were also evident of depression problem. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/9707 | 其他識別: | 912413H002008 | Rights: | 國立臺灣大學心理學系暨研究所 |
顯示於: | 心理學系 |
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912413H002008.pdf | 67 kB | Adobe PDF | 檢視/開啟 |
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