https://scholars.lib.ntu.edu.tw/handle/123456789/411183
標題: | Eicosapentaenoic acid protects cardiomyoblasts from lipotoxicity in an autophagy-dependent manner | 作者: | Hsu, Hsiu-Ching Li, Sin-Jin CHING-YI CHEN MING-FONG CHEN |
關鍵字: | Autophagy; Eicosapentaenoic acid; In vitro model; Lipotoxicity; Mitochondrial dynamics; Palmitic acid | 公開日期: | 2018 | 出版社: | SPRINGER | 卷: | 34 | 期: | 3 | 起(迄)頁: | 177 | 來源出版物: | Cell biology and toxicology | 摘要: | The cardiovascular health benefits of eicosapentaenoic acid (EPA) have been demonstrated previously; however, the exact mechanism underlying them remains unclear. Our previous study found that lipotoxicity induced cardiomyocyte apoptosis via the inhibition of autophagy. Accordingly, in this study, we investigated whether EPA attenuated lipotoxicity-induced cardiomyocyte apoptosis through autophagy regulation. The role of EPA in mitochondrial dynamics was analyzed as well. |
URI: | https://api.elsevier.com/content/abstract/scopus_id/85025586466 https://scholars.lib.ntu.edu.tw/handle/123456789/411183 |
ISSN: | 0742-2091 | DOI: | 10.1007/s10565-017-9406-9 |
顯示於: | 動物科學技術學系 |
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