https://scholars.lib.ntu.edu.tw/handle/123456789/412531
標題: | Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II | 作者: | Edwardson, J. Michael CHIH-TIEN WANG Gong, Belvin Wyttenbach, Andreas Bai, Jihong Jackson, Meyer B. Chapman, Edwin R. Morton, A. Jennifer |
公開日期: | 15-八月-2003 | 出版社: | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | 卷: | 278 | 期: | 33 | 起(迄)頁: | 30849 | 來源出版物: | Journal of Biological Chemistry | 摘要: | Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by an expanded CAG repeat in the HD gene. We reported recently that complexin II, a protein involved in neurotransmitter release, is depleted from both the brains of mice carrying the HD mutation and from the striatum of post mortem HD brains. Here we show that this loss of complexin II is recapitulated in PC12 cells expressing the HD mutation and is accompanied by a dramatic decline in Ca2+-triggered exocytosis of neurotransmitter. Overexpression of complexin II (but not complexin I) rescued exocytosis, demonstrating that the decline in neurotransmitter release is a direct consequence of complexin II depletion. Complexin II depletion in the brain may account for some of the abnormalities in neurotransmission associated with HD. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/412531 | ISSN: | 00219258 | DOI: | https://api.elsevier.com/content/abstract/scopus_id/0041731977 10.1074/jbc.M304615200 |
顯示於: | 分子與細胞生物學研究所 |
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J. Biol. Chem.-2003-Edwardson-30849-53.pdf | 226.71 kB | Adobe PDF | 檢視/開啟 |
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