https://scholars.lib.ntu.edu.tw/handle/123456789/412789
標題: | Association between low-grade inflammation and Breast cancer and B-cell Myeloma and Non-Hodgkin Lymphoma: findings from two prospective cohorts | 作者: | Berger, Eloise Delpierre, Cyrille Hosnijeh, Fatemeh Saberi Kelly-Irving, Michelle Portengen, Lutzen Bergdahl, Ingvar A Johansson, Ann-Sofie Krogh, Vittorio Palli, Domenico Panico, Salvatore Sacerdote, Carlotta Tumino, Rosario Kyrtopoulos, Soterios A Vineis, Paolo Chadeau-Hyam, Marc Vermeulen, Roel Castagn?, Rapha?le WEN-CHUNG LEE 李文宗 Lenner P. Bendinelli B. Botsivali M. Chatziioannou A. Valavanis I. Bodinier B. Garrido-Manriquez J. Athersuch T.J. Liquet B. Lokhorst H. Georgiadis P. Kleinjans J.C.S. De Kok T.M.C.M. Keun H.C. Kelly R. Hallmans G. Stephanou E.G. Myridakis A. Kogevinas M. Fazzo L. De Santis M. Comba P. Kiviranta H. Rantakokko P. Airaksinen R. Ruokojarvi P. Gilthorpe M. Fleming S. Fleming T. YU-KANG TU Lundh T. Chien K.-L. WEI J. CHEN Lee W.-C. CHUHSING KATE HSIAO PO-HSIU KUO Hung Hung HSIU-PO KUO |
公開日期: | 17-七月-2018 | 出版社: | NATURE PUBLISHING GROUP | 卷: | 8 | 期: | 1 | 來源出版物: | Scientific reports | 摘要: | Chronic inflammation may be involved in cancer development and progression. Using 28 inflammatory-related proteins collected from prospective blood samples from two case-control studies nested in the Italian component of the European Prospective Investigation into Cancer and nutrition (n = 261) and in the Northern Sweden Health and Disease Study (n = 402), we tested the hypothesis that an inflammatory score is associated with breast cancer (BC) and Β-cell Non-Hodgkin Lymphoma (B-cell NHL, including 68 multiple myeloma cases) onset. We modelled the relationship between this inflammatory score and the two cancers studied: (BC and B-cell NHL) using generalised linear models, and assessed, through adjustments the role of behaviours and lifestyle factors. Analyses were performed by cancer types pooling both populations, and stratified by cohorts, and time to diagnosis. Our results suggested a lower inflammatory score in B-cell NHL cases (β = -1.28, p = 0.012), and, to lesser, extent with BC (β = -0.96, p = 0.33) compared to controls, mainly driven by cancer cases diagnosed less than 6 years after enrolment. These associations were not affected by subsequent adjustments for potential intermediate confounders, notably behaviours. Sensitivity analyses indicated that our findings were not affected by the way the inflammatory score was calculated. These observations call for further studies involving larger populations, larger variety of cancer types and repeated measures of larger panel of inflammatory markers. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/412789 | ISSN: | 2045-2322 | DOI: | https://api.elsevier.com/content/abstract/scopus_id/85050189913 10.1038/s41598-018-29041-1 |
SDG/關鍵字: | breast tumor; case control study; cohort analysis; female; human; inflammation; male; metabolism; middle aged; multiple myeloma; nonhodgkin lymphoma; pathology; principal component analysis; theoretical model; Breast Neoplasms; Case-Control Studies; Cohort Studies; Female; Humans; Inflammation; Lymphoma, Non-Hodgkin; Male; Middle Aged; Models, Theoretical; Multiple Myeloma; Principal Component Analysis |
顯示於: | 流行病學與預防醫學研究所 |
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